Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes

Author(s): Alessandra B. Lopes*, Larissa B. Lopes, Roseli N. da Silveira Antunes, Josianne T. Fukasawa, Débora de A. Cavaretto, Zamir Calamita.

Journal Name: Current Aging Science

Volume 11 , Issue 2 , 2018

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Abstract:

Background: Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes, and Treg cells.

Objective: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation.

Methods: 49 elderlies (≥60 years) and 49 adults (≤35 years) were studied. Flow cytometry was used to analyze the expression of surface molecules and the subpopulation of Treg cells, and the results between the groups were compared statistically by the t-test.

Results: There was a decreased significance in the expression of CD11b and CD40 in the elderly.

Conclusion: Decreased CD11b expression can result in susceptibility to infectious diseases, and impairment of phagocytic capacity. Decreased CD40 expression can result in a decline in B lymphocyte activation. The other molecule studied presented alterations not significant, but compatible with the immunological changes in aging.

Keywords: Immunosenescence, aging, neutrophils, lymphocytes, CD11b, CD40.

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2018
Page: [118 - 125]
Pages: 8
DOI: 10.2174/1874609811666180605092234

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