Background: Immunosenescence is a remodeling of the immune system, caused by aging, with
changes in the function of neutrophils, lymphocytes, and Treg cells.
Objective: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils),
CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation.
Methods: 49 elderlies (≥60 years) and 49 adults (≤35 years) were studied. Flow cytometry was used to analyze
the expression of surface molecules and the subpopulation of Treg cells, and the results between the
groups were compared statistically by the t-test.
Results: There was a decreased significance in the expression of CD11b and CD40 in the elderly.
Conclusion: Decreased CD11b expression can result in susceptibility to infectious diseases, and
impairment of phagocytic capacity. Decreased CD40 expression can result in a decline in B lymphocyte
activation. The other molecule studied presented alterations not significant, but compatible
with the immunological changes in aging.