Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines

Author(s): Raquel P. Souza*, Patrícia S. Bonfim-Mendonça, Gabrielle M.Z.F. Damke, Analine R.B. de-Assis Carvalho, Bianca A. Ratti, Djaceli S. O. Dembogurski, Vânia R.S. da-Silva, Sueli O. Silva, Denise B. Da-Silva, Marcos L. Bruschi, Silvya S. Maria-Engler, Marcia E.L. Consolaro.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 12 , 2018

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Abstract:

Background: Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer.

Method: To explore a new therapeutic candidate for cervical cancer, we have evaluated the effects of artepillin C on cellular viability in a comprehensive panel of human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16- and 18-positive) and C33A (HPV-negative) cells compared to a spontaneously immortalized human epithelial cell line (HaCaT).

Results: Our results demonstrated that artepillin C had a selective effect on cellular viability and could induce apoptosis possibly by intrinsic pathway, likely a result of oxidative stress, in all cancer-derived cell lines but not in HaCaT. Additionally, artepillin C was able to inhibit the migration and invasion of cancer cells.

Conclusion: Thus, artepillin C appears to be a promising new candidate as an anticancer drug for cervical cancer induced by different HPV types.

Keywords: Artepillin C, propolis, cervical cancer, apoptosis, cell migration and invasion, oxidative stress.

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Article Details

VOLUME: 18
ISSUE: 12
Year: 2018
Page: [1750 - 1760]
Pages: 11
DOI: 10.2174/1871520618666180604092930
Price: $58

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