Medicinal Chemistry for Pharmacy Students

Medicinal Chemistry for Pharmacy Students

Fundamentals of Medicinal Chemistry and Drug Metabolism

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical ...
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Solubility and Lipid-Water Partition Coefficient

Pp. 109-130 (22)

Hardeep Singh Saluja and M. O. Faruk Khan

Abstract

This chapter is brief review of solubility and related concepts, lipid-water partition coefficients and their significance in drug bioavailability. After study of this chapter, students will be able to: • Analyze and predict the solubility of drugs. • Identify factors affecting the solubility of drugs. • Project the polarity, hydrophilicity, hydrophobicity, lipophilicity of drugs and their influence on solubility. • Predict the water or lipid solubility of drugs from their structures. • Comprehend the concept of partition coefficient. • Apply the concept of lipid water partition coefficient (LWPC) and its significance in drug bioavailability and action.

Keywords:

Hydrophobicity, Hydrophilicity, Lipid-water partition coefficient, Lipophilicity, Solubility, Water solubilizing potential.

Affiliation:

Department of Pharmaceutical Sciences and Research, Marshall University School of Pharmacy, Huntington, West Virginia, USA.