Cancer-associated fibroblasts (CAFs) are an important cell type present in solid tumor microenvironments,
including that of gastric cancer. They play a vital role in the promotion of tumorigenesis, angiogenesis,
and cancer progression through paracrine signaling and modulation of the extracellular matrix. However, the
exact molecular mechanism underlying the interaction between gastric cancer cells and stromal fibroblasts remains
poorly understood. Recent studies have demonstrated that various factors, such as gene and microRNA
variations, are involved in this process. This review discusses recent advances in understanding how these factors
are regulated in CAFs and how they affect tumor biology, which may improve our understanding of their role in
gastric cancer tumorigenesis and progression and provide new promising targets for therapeutic strategies.
Keywords: Cancer-associated fibroblasts, tumor microenvironment, gastric cancer, tumorigenesis, angiogenesis, extracellular matrix.
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