Kinetics of the Solution-Mediated Polymorphic Transformation of Organic Compounds

Author(s): Lek Wantha*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 21 , 2018


Abstract:

Polymorphism is a behavior of a substance to crystallize into more than one district crystal structures. Preferential formation of a polymorph depends strongly on the kinetics of the relevant mechanisms. Solutionmediated polymorphic transformation is an important mechanism in crystallization of organic compounds from solution. Knowing its kinetics allows us to understand the process and control the polymorphic formation. In this review, concepts, kinetics, and process modeling of crystallization and solution-mediated polymorphic transformation are examined and summarized.

Keywords: Polymorphism, organic compound, crystallization from solution, kinetics, solution-mediated polymorphic transformation, process modelling.

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Article Details

VOLUME: 24
ISSUE: 21
Year: 2018
Page: [2383 - 2393]
Pages: 11
DOI: 10.2174/1381612824666180601093228
Price: $58

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