MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy

Author(s): Yi Yang , Ning Zhang , Shan Wang , Ya Wen* .

Journal Name: Current Neurovascular Research

Volume 15 , Issue 2 , 2018

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Abstract:

Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury. Subsequently, miR-155- induced autophagy modifies inflammatory responses through regulating TLR4/NF-κB pathway in ischemic cerebral tissues. Thus, miR-155 elevated autophagy is detrimental for ischemic cerebral injury and miR-155-induced autophagy modulates inflammatory responses through activating TLR4/NF-κB pathway.

Keywords: miR-155, autophagy, inflammatory response, ischemic cerebral tissues, ischemic stroke, hypoxic damages.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2018
Page: [103 - 110]
Pages: 8
DOI: 10.2174/1567202615666180601081409
Price: $58

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