Protein-Protein Interactions (PPIs) are the key components in many cellular processes including
signaling pathways, enzymatic reactions and epigenetic regulation. Abnormal interactions of some
proteins may be pathogenic and cause various disorders including cancer and neurodegenerative diseases.
Although inhibiting PPIs with small molecules is a challenging task, it gained an increasing interest
because of its strong potential for drug discovery and design. The knowledge of the interface as well
as the structural and chemical characteristics of the PPIs and their roles in the cellular pathways is necessary
for a rational design of small molecules to modulate PPIs. In this study, we review the recent progress
in the field and detail the physicochemical properties of PPIs including binding hot spots with a
focus on structural methods. Then, we review recent approaches for structural prediction of PPIs. Finally,
we revisit the concept of targeting PPIs from a systems biology perspective and we refer to approaches
that are usually employed when the structural information is not present.
Keywords: Protein-protein interactions, cellular processes, epigenetic regulation, pathways, structural information, molecules.
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