Fasciola Hepatica Extract Induces Cell Death of Mammalian Cells

Author(s): Stephanie Ferreira, Ruben Fernandes, Monica C. Botelho*.

Journal Name: Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry

Volume 16 , Issue 2 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Background: Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. The International agency for Research on Cancer, states that O. viverrini and C. sinensis, also liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis caused by F. hepatica has not been associated with cancer to date. There are not any known causative associations between this parasite and liver cancer (cholangiocarcinoma).

Methods: Chine Hamster Ovary (CHO) cells were treated with F. haepatica extracts and cell proliferation was assessed by using the indirect method for estimating cell number based on the mitochondrial activity with MTS cell proliferation reagent. We observed unexpected death of these cells when treated with F. haepatica extracts.

Results and Conclusion: We now hypothesize that this parasite could be used as a medically-important trematode pathogen in cancer therapy.

Keywords: Fasciola hepatica, mammalian cells, cholangiocarcinoma, O. viverrini, C. sinensis, Chine Hamster Ovary (CHO).

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2018
Page: [144 - 146]
Pages: 3
DOI: 10.2174/1570180815666180531102555
Price: $58

Article Metrics

PDF: 20