Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall

Author(s): Katariina Öörni*, Satu Lehti, Peter Sjövall, Petri T. Kovanen.

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 9 , 2019

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Abstract:

Apolipoprotein B –containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low-density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial wall, where they accumulate and induce the formation of atherosclerotic lesions. The processes that lead to accumulation of lipoprotein-derived lipids in the arterial wall have been largely studied with a focus on the low-density lipoprotein particles. However, recent observational and genetic studies have discovered that the triglyceriderich lipoproteins and their remnants are linked with cardiovascular disease risk. In this review, we describe the potential mechanisms by which the triglyceride-rich remnant lipoproteins can contribute to the development of atherosclerotic lesions, and highlight the differences in the atherogenicity between low-density lipoproteins and the remnant lipoproteins.

Keywords: Chylomicron, VLDL, remnant, triglyceride, cholesterol, atherosclerosis, inflammation.

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VOLUME: 26
ISSUE: 9
Year: 2019
Page: [1701 - 1710]
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DOI: 10.2174/0929867325666180530094819
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