Cellular Senescence-Inducing Small Molecules for Cancer Treatment

Author(s): Peng Liu , Ziwen Lu , Yanfang Wu , Dongsheng Shang , Zhicong Zhao , Yanting SHEN , Yafei Zhang , Feifei Zhu , Hanqing Liu* , Zhigang Tu* .

Journal Name: Current Cancer Drug Targets

Volume 19 , Issue 2 , 2019

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Abstract:

Recently, the chemotherapeutic drug-induced cellular senescence has been considered a promising anti-cancer approach. The drug-induced senescence, which shows both similar and different hallmarks from replicative and oncogene-induced senescence, was regarded as a key determinant of tumor response to chemotherapy in vitro and in vivo. To date, an amount of effective chemotherapeutic drugs that can evoke senescence in cancer cells have been reported. The targets of these drugs differ substantially, including senescence signaling pathways, DNA replication process, DNA damage pathways, epigenetic modifications, microtubule polymerization, senescence-associated secretory phenotype (SASP), and so on. By summarizing senescence-inducing small molecule drugs together with their specific traits and corresponding mechanisms, this review is devoted to inform scientists to develop novel therapeutic strategies against cancer through inducing senescence.

Keywords: Cancer, senescence, small molecule drugs, DNA damage responses, senescence-related signaling pathways, SASP.

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VOLUME: 19
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Year: 2019
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DOI: 10.2174/1568009618666180530092825
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