Background: Topical infections, involving a number of diseases such as impetigo,
eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the
many challenges to health which stand out for their profound impact on human species. The
treatment of topical infections has always been a difficult proposition because of the lack of
efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery.
The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus,
Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa
undermines the need for the development of new delivery systems to enhance the therapeutic
efficacy of existing topical anti-infectives.
Methods: The application of nanotechnology to medicine, or nanomedicine, is rapidly becoming
a major driving force behind ongoing changes in the anti-infective field because of
its interaction at the sub-atomic level with the skin tissue. The latter, in the current scenario,
points towards vesicular carriers like liposomes, lipidic nanoparticles and silver nanoparticles.
as the most promising drug delivery solutions for topical infection disorders. These
have exhibited immense significance owing to their uniqueness to facilitate the interactions
at interfaces with the barrier membranes.
Results: The present review summarizes the emerging efforts in combating topical infections
particularly using nanomedicine based delivery systems as new tools to tackle the current
challenges in treating infectious diseases. Besides, compiling various research reports,
this article also includes formulation considerations, mechanisms of penetration and patents
Conclusion: Despite the new emerging technologies and delivery systems, efforts are still
needed in the right direction to combat this global challenge.