The Several Activities of 4 - Methyl Pyrazole in Animals and Humans

Author(s): Gaetano Iaquinto*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 18 , 2018

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Abstract:

4-MP is a potent competitive inhibitor of ADH activity with an affinity about a 1000 times more than toxic alcohols. 4-MP was shown to reduce the formation of toxic metabolites in lethal methanol and ethylene glycol poisoning in animal models and in methanol poisoning in humans. 4-MP has long-lasting gastroprotective effect against ethanol and other chemically induced acute gastric mucosa lesions in rats. We showed, for the first time, that 4-MP also provides significant protection of the human stomach against alcohol induced acute mucosal injury.

Keywords: 4 methyl pyrazole, alchol gastric, mucosal injury, gastroprotection, ADH, ethanol, alcohol.

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Article Details

VOLUME: 24
ISSUE: 18
Year: 2018
Page: [1957 - 1960]
Pages: 4
DOI: 10.2174/1381612824666180529081328
Price: $58

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