Multi-Target Antitubercular Drugs

Author(s): Jessika de Oliveira Viana , Hamilton Mitsugu Ishiki , Marcus Tullius Scotti , Luciana Scotti* .

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 9 , 2018

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Abstract:

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis.

Keywords: Anti tuberculosis drugs, Tuberculosis, Multi-target drugs, Targeting, Inhibition, Mycobacterium tuberculosis.

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Article Details

VOLUME: 18
ISSUE: 9
Year: 2018
Page: [750 - 758]
Pages: 9
DOI: 10.2174/1568026618666180528124414
Price: $58

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