Background: The gastrointestinal tract harbours a diverse bacterial community that contributes
to health and disease. A number of studies have demonstrated that the gut microbiota plays a critical
role in the metabolism of serotonin.
Methods: Microbial-derived metabolites, such as bile acids and short-chain fatty acids, are reported to
affect the production of serotonin which, in turn, directly or indirectly regulates gut motility. Enterochromaffin
cells are important specialized endocrine cells found in the intestine, which is the major location
of serotonin biosynthesis. The relationship between microbiota and gut motility are studied depended
on microbial-derived metabolites and serotonin.
Results and Conclusion: Both bile acids and short-chain fatty acids can modulate serotonin metabolism
in hosts by affecting key intermediates of the serotonin pathway. Thus, gut motility may be regulated
through microbial modifications of host serotonin biosynthesis, which continues to be evaluated
as a target for functional gastrointestinal disorders.