1,2,4-Oxadiazole as a Privileged Scaffold for Anti-inflammatory and Analgesic Activities: A Review

Author(s): Gita Chawla*.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 18 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

1,2,4-Oxadiazole is one of the important heterocycles used by medicinal chemists in designing a new therapeutic molecule. The compounds containing this nucleus are reported to have a wide range of pharmaceutical and biological applications including anti-inflammatory and analgesic activities. The fused and pendent 1,2,4-oxadiazole moiety has been traced in a number of well established, commercially available drugs. This review article provides an up to date information about techniques adopted for the synthesis of 1,2,4-oxadiazoles, and their therapeutic importance as anti-inflammatory and analgesic agents.

Keywords: 1, 2, 4-Oxadiazole, NSAIDs, COX, anti-inflammatory, analgesic, COX.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 18
ISSUE: 18
Year: 2018
Page: [1536 - 1547]
Pages: 12
DOI: 10.2174/1389557518666180524112050
Price: $58

Article Metrics

PDF: 28
HTML: 7