1,2,4-Oxadiazole is one of the important heterocycles used by medicinal chemists in designing
a new therapeutic molecule. The compounds containing this nucleus are reported to have a wide
range of pharmaceutical and biological applications including anti-inflammatory and analgesic activities.
The fused and pendent 1,2,4-oxadiazole moiety has been traced in a number of well established,
commercially available drugs. This review article provides an up to date information about techniques
adopted for the synthesis of 1,2,4-oxadiazoles, and their therapeutic importance as anti-inflammatory
and analgesic agents.
Keywords: 1, 2, 4-Oxadiazole, NSAIDs, COX, anti-inflammatory, analgesic, COX.
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