Background: Candidiasis is one of the most common opportunistic fungal infections caused by genus
Candida. The genus is composed of around 200 species. The most virulent among all are, Candida albicans followed
by various nonalbicans species. Despite various treatments available, the incidence of severe systemic
fungal infections is increasing, and with it the related morbidity and mortality, in relation to the misuse of antimicrobials
and the emergence of drug-resistant fungal species. Therefore, various novel therapeutic approaches need
to be developed and explored to overcome these limitations and effective management of candidiasis.
Objective: In this review, we focused on natural herbal remedies and significance of novel formulation approaches
for the treatment of candidiasis.
Conclusion: The reported studies suggested the promising role of phytomedicines and novel polymeric drug
delivery systems in therapeutic management of candidiasis. Phytomedicines are effective substitutes of synthetic
drugs as they are inexpensive with lesser number of side effects. Various novel particulate approaches can be
successfully used to reduce fungal burden at the target site.