Progress of Oral Insulin and Related Drug Delivery Systems and their Pharmacokinetics

Author(s): Jingjing Chen, Rui Liu*, Changxiao Liu*, Xin Jin, Qinghua Zhang, Jialu Wang, Fang Zhao, Ze Wang, Haiyan Qiu, Yazhuo Li, Xiulin Yi.

Journal Name: Current Drug Metabolism

Volume 19 , Issue 10 , 2018


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Abstract:

Background: As society has developed and living standards have improved, diabetes has become a severe public health issue. Insulin plays a crucial role in managing hyperglycemia caused by type I diabetes and particular type II diabetes. Many researchers are seeking alternative, more acceptable methods of insulin delivery, such as oral insulin. An oral formulation has become a new goal for insulin delivery in recent years.

Methods: The PubMed and CNKI databases were searched for “oral insulin, ” “drug delivery systems, ” and “pharmacokinetics, ” and 85 relevant articles were selected from the results as material for this review. These papers were authoritative and had a higher number of citations.

Results: Oral insulin would be highly advantageous but is poorly absorbed. The main reason for low absorptivity is the hydrolysis of insulin by enzymes in the gastrointestinal tract. Lack of active transport vectors that pass through the intestinal epithelium is also a non-negligible problem. Additional issues need to be considered to facilitate appropriate research, such as long-term efficacy and safety, clinical data, and toxicological characteristics.

Conclusion: This review summarized recent advances in oral insulin and the pharmacokinetic profile of the suitable delivery system, providing valuable reference material for future research.

Keywords: Diabetes, insulin, oral preparation, dosage forms, progress, drug delivery systems, metabolism.

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Article Details

VOLUME: 19
ISSUE: 10
Year: 2018
Page: [863 - 870]
Pages: 8
DOI: 10.2174/1389200219666180523101434
Price: $58

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