Biologics for the Treatment of Juvenile Idiopathic Arthritis

Author(s): Dimitri Poddighe*, Micol Romano, Maurizio Gattinara, Valeria Gerloni.

Journal Name: Current Medicinal Chemistry

Volume 25 , Issue 42 , 2018

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Abstract:

Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic diseases in children. Recently, the management of JIA has substantially changed, thanks to the availability of new treatment options, represented by biological drugs or biologics. These drugs modulate the specific mechanisms of the immune systems, such as TNF-α, IL-1 and IL-6 signaling, or lymphocyte activation and/or functioning. In this review, we provide a comprehensive discussion on the current recommendations and clinical evidence regarding the use of the available biologics in the treatment of JIA; moreover, the main pharmacokinetic and pharmacodynamic aspects of any specific biologic drug have been summarized.

Keywords: Biologics, JIA, clinical evidence, immunology, pharmacodynamics, pharmacokinetics.

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Article Details

VOLUME: 25
ISSUE: 42
Year: 2018
Page: [5860 - 5893]
Pages: 34
DOI: 10.2174/0929867325666180522085716
Price: $58

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