Association Between Delayed Graft Function (DGF) Biomarkers and Long-term Outcomes After Living Donor Kidney Transplantation

Author(s): Zahra Sahraei, Mona Mehdizadeh, Jamshid Salamzadeh, Mohsen Nafar, Azadeh Eshraghi*.

Journal Name: Reviews on Recent Clinical Trials

Volume 13 , Issue 4 , 2018

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Abstract:

Background and Objectives: The association between preoperative Urine Neutrophil Gelatinase-associated Lipocalin (uNGAL) and interleukin-18 (uIL-18) with poor 1-year allograft function has been shown in deceased-donor kidney transplant recipients previously, and also these markers could predict 3-month allograft function. However, it is unknown whether there is an association between these postoperative biomarkers with important recipient outcomes beyond this time in livedonor transplants.

Methods: NGAL and IL-18 four and 24 hours were measured in live-donor kidney transplant recipients after transplantation. The relationships between changes in these markers with clinical outcomes as well as kidney function were examined at 1 month and 2 years. Moreover, the association between delayed graft function with clinical outcome and Serum Creatinine (SrCr) was evaluated during this period.

Results: The Mean age for kidney recipients was 23.9 years. Significant interaction was observed between uNGAL 24 hr (pvalue=0.01) and uIL-18 four and 24 hr after transplantation (pvalue=0.04, 0.03; respectively) with patients’ outcome after 1 month and changes in uNGAL with outcomes after 2 years (pvalue= 0.04).

Conclusion: Changes in urine NGAL postoperative are associated with worst outcomes, 2 years after kidney transplantation, suggesting its potential role in identifying patients that are at high risk for diminished allograft function, outcome and survival.

Keywords: Delay Graft Function, interleukin 18, urine neutrophil gelatinase-associated lipocalin, kidney transplant, serum creatinine (SrCr), urine output (UO).

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2018
Page: [312 - 318]
Pages: 7
DOI: 10.2174/1574887113666180522082930
Price: $58

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