The Development of New Small-Molecule Inhibitors Targeting Bacterial Metallo-β-lactamases

Author(s): Ping Wang, Jing Cheng, Cong-Cong Liu, Kai Tang, Feng Xu, Zhiqiang Yu, Bin Yu*, Junbiao Chang*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 10 , 2018

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Abstract:

Metallo-β-lactamases (MBLs) are a family of Zn(II)-dependent enzymes that can hydrolyze almost all β-lactam antibiotics. Horizontal transfer of the genes encoding MBLs among Gram-negative bacteria pathogens has led to the emergence of extensively drug-resistant pathogens, which now represent a major threat to human health. As there is not to date yet a clinically available MBL inhibitor, the discovery of new MBL inhibitors has great urgency. This review highlights the recent developments in the discovery of small-molecule MBL inhibitors.

Keywords: Metallo-β-lactamases, thiol derivatives, dicarboxylic acid derivatives, cyclic Boronates, triazoles, natural products, peptide inhibitors.

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Article Details

VOLUME: 18
ISSUE: 10
Year: 2018
Page: [834 - 843]
Pages: 10
DOI: 10.2174/1568026618666180518101028
Price: $58

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