An Efficient and Straightforward Total Synthesis of (±)-Preclamol

Author(s): Ravi Lakkakula, K. Mukkanti, Arnab Roy*.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 12 , 2018

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Abstract:

A prudent and scalable synthesis of (±)-Preclamol is described utilizing Michael addition and in-situ reduction/cyclization of an aryl-α-carbethoxy acetonitrile derivative as a key step.

Keywords: Michael addition, in-situ reduction/cyclization, preclamol, risperidone, alogliptin, ritalin.

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Article Details

VOLUME: 15
ISSUE: 12
Year: 2018
Page: [1065 - 1069]
Pages: 5
DOI: 10.2174/1570178615666180518090406
Price: $65

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