Nanocrystals Technology for Pharmaceutical Science

Author(s): Zhongyao Cheng, Yumei Lian, Zul Kamal, Xin Ma, Jianjun Chen, Xinbo Zhou*, Jing Su*, Mingfeng Qiu*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 21 , 2018


Abstract:

Background: Nanocrystals technology is a promising method for improving the dissolution rate and enhancing the bioavailability of poorly soluble drugs. In recent years, it has been developing rapidly and applied to drug research and engineering. Nanocrystal drugs can be formulated into various dosage forms.

Objective: This review mainly focused on the nanocrystals technology and its application in pharmaceutical science. Firstly, different preparation methods of nanocrystal technology and the characterization of nanocrystal drugs are briefly described. Secondly, the application of nanocrystals technology in pharmaceutical science is mainly discussed followed by the introduction of sustained release formulations. Then, the scaling up process, marketed nanocrystal drug products and regulatory aspects about nanodrugs are summarized. Finally, the specific challenges and opportunities of nanocrystals technology for pharmaceutical science are summarized and discussed.

Conclusion: This review will provide a comprehensive guide for scientists and engineers in the field of pharmaceutical science and biochemical engineering.

Keywords: Nanocrystals technology, poorly soluble drugs, delivery, scale-up, market, regulatory.

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Article Details

VOLUME: 24
ISSUE: 21
Year: 2018
Page: [2497 - 2507]
Pages: 11
DOI: 10.2174/1381612824666180518082420
Price: $58

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