Since 1929, several researchers have conducted studies in relation to the nucleoside of
adenosine (1) mainly distribution identifying, characterizing their biological importance and synthetic
chemistry to which this type of molecule has been subjected to obtain multiple of its derivatives. The
receptors that interact with adenosine and its derivatives, called purinergic receptors, are classified as
A1, A2A, A2B and A3. In the presence of agonists and antagonists, these receptors are involved in various
physiological processes and diseases.
This review describes and compares some of the synthetic methods that have been developed over the
last 30 years for obtaining some adenosine derivatives, classified according to substitution processes,
complexation, mating and conjugation. Finally, we mention that although the concentrations of these
nucleosides are low in normal tissues, they can increase rapidly in pathophysiological conditions such
as hypoxia, ischemia, inflammation, trauma and cancer. In particular, the evaluation of adenosine derivatives
as adjunctive therapy promises to have a significant impact on the treatment of certain cancers,
although the transfer of these results to clinical practice requires a deeper understanding of how
adenosine regulates the process of tumorigenesis.