Hypertensive disorder of pregnancy, especially Pre-eclampsia is one of the major causes
of increased maternal and perinatal morbidity and mortality all over the world. Early prediction of
pre-eclampsia is the need of modern obstetrics, as this can timely prevent the progress of disease as
well as related fetal and maternal morbidity and mortality. In addition to the screening of fetal aneuploidies,
Rhesus-D status, fetal sex, single gene disorders, the cell-free fetal Deoxyribonucleic acid
(DNA) quantification has emerged as a promising biomarker for the prediction of pre-eclampsia.
Hence, its use can help in the early prediction of hypertensive disorders of pregnancy, especially
pre-eclampsia even before the appearance of symptoms. Furthermore, in future, it can also help in
the determination of the complete DNA sequence of every gene of the fetus. The present review
focuses on recent literature concerning the use of cell-free fetal DNA in early prediction of preeclampsia
as well as for non-invasive prenatal genetic screening of fetus for various disorders.
Methods: The recent literature related to cell-free fetal DNA was searched from numerous English
language journals and published peer-reviewed articles on Pubmed, Google Scholar, MEDLINE
and various government agencies till 2016.