Increased Serum Total Bile Acids can be Associated with a Small Hematoma Volume and Decreased Clinical Severity During Acute Intracerebral Hemorrhage

Author(s): Kaili Wang, Yu Zhang, Chongke Zhong, Danni Zheng, Jiaping Xu, Yanlin Zhang, Jijun Shi, Goudong Xiao, Xia Zhang, Huihui Liu, Zhichao Huang, Chun-Feng Liu, Shoujiang You*, Yongjun Cao*.

Journal Name: Current Neurovascular Research

Volume 15 , Issue 2 , 2018

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Abstract:

Background: The impact of Total Bile Acids (TBA) level on clinical outcomes after acute Intracerebral Hemorrhage (ICH) is still not understood.

Objective: We investigated whether admission TBA level is associated with hematoma volume, stroke clinical severity, and 3-month outcomes in acute ICH patients.

Methods: A total of 335 ICH patients were prospectively enrolled. Patients were divided into four groups, according to the quartiles of serum TBA level at the time of admission. Three-month outcomes were evaluated by interviews with patients or their family members.

Results: The median hematoma volumes for the quartiles of TBA level (Q1 to Q4) were 12.0, 12.3, 10.0, and 6.7 mL (P<0.001) and the median National Institutes of Health Stroke Scale (NIHSS) scores were 8, 8, 6, and 5 (P=0.002), respectively. In the adjusted models, patients in the highest quartile (Q4) had smaller hematoma volumes (P=0.039) and lower NIHSS scores (P=0.037) than patients in Q1. At three months follow-up, there were 136 patients with poor outcomes (defined as having modified Rankin Scale scores≥3) and 46 cases of all-cause deaths. TBA level was not significantly associated with poor outcome nor all-cause death after adjusting for age, sex, hematoma volume, and baseline NIHSS(all P-trend≥0.380).

Conclusions: Higher admission TBA was associated with smaller hematoma volume and decreased clinical severity, but not three month outcomes in patients with acute ICH.

Keywords: Total bile acids, intracerebral hemorrhage, hematoma volume, prognosis, stroke, coronary artery disease.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2018
Page: [158 - 163]
Pages: 6
DOI: 10.2174/1567202615666180516114211
Price: $58

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