Background and Objective: Bio-soft material, a class of derivatives of the natural or synthetic material,
is getting more and more prevalent in biomedical researches and applications due to the advantages such as
in-vivo biodegradation, good water solubility and designable targeting ability. With the presence of bio-soft materials,
the drug nanocrystal can be easily generated and aggregated in a feasible process. Given the promising
application of the bio-soft material in biological and chemical research, it is valuable to discuss the crucial step in
designing bio-soft materials and analyze the emerging properties of bio-soft materials.
Methods: A comprehensive literature survey in the field of bio-soft material development and analysis has been
conducted. The collected data and figures were meticulously analyzed and interpreted.
Results: In this review, the details of bio-soft materials based nanocrystal were demonstrated in three sections
with respect to different materials. In each section, the pros and cons for each bio-soft material and its derivatives
were elaborately listed and discussed.
Conclusion: The review enables an insightful discussion about the properties and the applications of existing biosoft
material. It may contribute to the further researches about bio-soft material development and analysis.