Background and Objective: Nanocrystal technology is an effective approach which can increase the
dissolution rate of poorly water-soluble drugs by raising their saturation solubility, thus improving the drug
bioavailability. With the development of nanocrystals, its preparation approaches have gradually matured, which
can be generally divided into Bottom-up, Top-down and Combinative technologies.
Methods: A systematic literature review in the field of nanocrystal technology for the cancer treatment was
scanned and collected data was detailedly analyzed and summarized.
Results: Over the past decade, several anticancer drug nanocrystals have been explored and evaluated in preclinical
studies and clinical trials. This review mainly covers the utilizations of the nanocrystal technology in enhancing
the saturation solubility of anticancer drugs associated with the increased bioavailability and anticancer efficacy.
Preparation methods and characterizations of nanocrystals are also introduced in brief. In addition, one
critical step in the formation of drug nanocrystals is selecting suitable stabilizers for the system. Many types of
research are heading towards the role of the stabilizers in the final nanocrystals formulation. So we summed up
several commonly used stabilizers in order to give a reference to the further study. At last, we discussed some
considerations raised by the application of nanocrystal drugs for cancer treatment.
Conclusion: This review is likely to enable a detailed insight on nanocrystal technology as a strategy to improve
drug bioavailability and antitumor efficacy for the cancer treatment and be of particular interest to pharmaceutical