The time window for neuroprotection during ischemic brain stroke is short, and hence, development of
neuroprotectants is critical to extend this time window. This study sought to verify if muco-adhesive chitosan
coating improves the neuroprotective potential of the pre-proven C-Phycocyanin-pertaining liposome (C-Pc
liposome). The use of chitosan-coated liposomes extended the neuroprotective time window by 6 h after occlusion,
and further improved the neuroprotection efficiency of the C-Pc liposome in a rat Middle Cerebral Artery
Occlusion (MCAO) model. Beneficial changes in mRNA expressions of antioxidants, inflammatory cytokines
and glia scar proteoglycans were evident in the C-Pc liposomes. In addition, in the cultured astrocytes, the chitosan-
coated C-Pc liposome expressed anti-oxidative activity without cytotoxicity.
Keywords: Chitosan, C-phycocyanin, neuroprotection, liposome, ischemia and reperfusion, brain stroke.
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