Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke

Author(s): Goo Yong Chung, Kyou Hee Shim, Hye Jin Kim, Seul Ki Min, Hwa Sung Shin*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 17 , 2018

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Abstract:

The time window for neuroprotection during ischemic brain stroke is short, and hence, development of neuroprotectants is critical to extend this time window. This study sought to verify if muco-adhesive chitosan coating improves the neuroprotective potential of the pre-proven C-Phycocyanin-pertaining liposome (C-Pc liposome). The use of chitosan-coated liposomes extended the neuroprotective time window by 6 h after occlusion, and further improved the neuroprotection efficiency of the C-Pc liposome in a rat Middle Cerebral Artery Occlusion (MCAO) model. Beneficial changes in mRNA expressions of antioxidants, inflammatory cytokines and glia scar proteoglycans were evident in the C-Pc liposomes. In addition, in the cultured astrocytes, the chitosan- coated C-Pc liposome expressed anti-oxidative activity without cytotoxicity.

Keywords: Chitosan, C-phycocyanin, neuroprotection, liposome, ischemia and reperfusion, brain stroke.

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Article Details

VOLUME: 24
ISSUE: 17
Year: 2018
Page: [1859 - 1864]
Pages: 6
DOI: 10.2174/1381612824666180515123543
Price: $58

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