Drugs for the Treatment of Mitochondrial Diseases

Author(s): Diego F. Gomez-Casati* , Maria V. Busi .

Journal Name: Current Chemical Biology

Volume 13 , Issue 1 , 2019

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Abstract:

Background: Mitochondrial diseases are a complex group of pathologies caused by mutations in genes coded in the nuclear and/or the mitochondrial DNA, which fulfill their function in the organelle. The diagnosis is also complex, since it depends on the integration of biochemical, histological and imaging data.

Objective: In this paper we review the use of some of these substances and their efficacy in the treatment of these disorders.

Conclusions: Currently, there is not a fully effective treatment, however, it was demonstrated that the use of some vitamins, amino acids, antioxidants along with a proper diet and exercise have an important effect that leads to improve the overall state of patients with mitochondrial disorders.

Keywords: Mitochondria, diseases, reactive oxygen species, mitochondrial drugs, pharmacological approaches, vitamins, antioxidants.

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2019
Page: [19 - 24]
Pages: 6
DOI: 10.2174/2212796812666180515122303
Price: $58

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