Endocrine Disrupting Chemical Induced “Pollution of Metabolic Pathways”: A Case of Shifting Paradigms With Implications for Vascular Diseases

Author(s): Rajiv Janardhanan*.

Journal Name: Current Drug Targets

Volume 19 , Issue 9 , 2018

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Graphical Abstract:


The latter half of the twentieth century has witnessed a humongous spurt in the use of synthetic chemicals in a wide variety of industrial and agricultural applications leading to specific perturbations affecting every trophic level of the ecosystems due to unmitigated environmental contamination. Despite the incremental usefulness of endocrine disrupting chemicals (EDCs) such as pesticides and plasticizers, their statutory impact on environmental health is assuming worrisome proportions. The EDCs can disrupt physiological homeostasis resulting in developmental and reproductive abnormalities. Both preclinical animal experiments, as well as epidemiological studies, have correlated EDC exposure with metabolic disorders such as metabolic syndrome, type 2 diabetes as well as cardiovascular health. Here we briefly review the statutory impact of EDCs on metabolic disruption as well as their impact on environmental health. Finally, difficulties pertaining to the categorization of EDC induced metabolic diseases as risk factors for global disease burden have been addressed taking into account the complexity of such interactions.

Keywords: Endocrine disrupting chemicals, metabolic pathways, risk factors, global disease burden, vascular disease, metabolic disorders.

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Article Details

Year: 2018
Page: [1024 - 1037]
Pages: 14
DOI: 10.2174/1389450119666180514122244
Price: $58

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