The latter half of the twentieth century has witnessed a humongous spurt in the use of synthetic
chemicals in a wide variety of industrial and agricultural applications leading to specific perturbations
affecting every trophic level of the ecosystems due to unmitigated environmental contamination.
Despite the incremental usefulness of endocrine disrupting chemicals (EDCs) such as pesticides
and plasticizers, their statutory impact on environmental health is assuming worrisome proportions.
The EDCs can disrupt physiological homeostasis resulting in developmental and reproductive abnormalities.
Both preclinical animal experiments, as well as epidemiological studies, have correlated
EDC exposure with metabolic disorders such as metabolic syndrome, type 2 diabetes as well as cardiovascular
health. Here we briefly review the statutory impact of EDCs on metabolic disruption as
well as their impact on environmental health. Finally, difficulties pertaining to the categorization of
EDC induced metabolic diseases as risk factors for global disease burden have been addressed taking
into account the complexity of such interactions.
Keywords: Endocrine disrupting chemicals, metabolic pathways, risk factors, global disease burden, vascular disease, metabolic
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