Glioblastoma multiforme (GBM) is the most frequent glioma with a poor prognosis.
The mainstay treatment for GBM is chemotherapy, but the average survival of GBM remains
unsatisfactory due to therapeutic resistance. Poor permeability restricted by the blood
brain barrier (BBB) and the presence of glioblastoma stem cells (GSCs) remain as two problems
for chemotherapy. Recently, nanocarriers have attracted much attention in the research
of GBM, owing to their advantages in self-assembly, biosafety, release controllability, and
BBB penetrability, making them promising candidates for GBM treatment. This article aims
to review the biologic signatures of BBB and GSCs, as well as the new development of nanodrug
delivery systems to facilitate our understanding of targeted treatment for GBM.
Keywords: Glioblastoma multiforme, brain blood barrier, glioblastoma stem cells, nanocarriers, lipids, gold, targeted therapy.
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