Alzheimer's disease (AD) is a neurodegenerative disease that is reducing progressively
the part cognitive inside the Central Nervous System (CNS) and that affects the memories
and emotions of the patients who endure this disease. Many drugs have been assessed in
patients with different evolutionary grades of the disease, having diverse results, depending
on the used compound. Some of them afford dependence and many others with side effects
that affect the emotional part and the economic cost of the treatment. The natural products
have diversified their therapeutic uses, and have been used in the treatment of AD in accordance
with its easy medical administration and bioavailability. In this review, the use of aporphines
in nature for treating Alzheimer's disease, alkaloids isolated from natural and/or synthetic
sources have been used principally as cholinesterase inhibitors (acetyl- and butyrylcholinesterase)
as galantamine, for instance, though its use has been questioned for being slightly
effective or marginal. The use of aporphines gives the possibility of generating new treatments
with nitrogenous chemical structures of diverse complexity and that are focused in this
review comparatively and with real therapeutic scopes.
Keywords: Aporphines, apomorphine, oxoaporphines, Alzheimer’s disease, dopamine, neurodegenerative disease.
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