Background: Despite extensive advances have been made in constructing polysaccharide-based
nanomedicines for target cancer therapy due to their biocompatibility, easy-functionalizability and high targeting
property, there is no review concentrating the significance of the intrinsic targeting properties of polysaccharides.
This review mainly focuses on the recent progress on polysaccharide-based nanoparticles which have been applied in
gene delivery, drug delivery and theranostics for targeted cancer therapies. Notably, representative polysaccharides
with intrinsic targeting capability used as targeting ligand are well discussed.
Conclusion: It has been found that polysaccharides have become a class of promising biopolymer carrier materials to
deliver anti-cancer therapeutic molecules. Among all of polysaccharides, those who are with intrinsic properties of
targeting are most frequently used. Therefore, this review revealed the importance of understanding the natural functions
of polysaccharides to tailor nanocarrier platforms and ultimately surmount challenges in targeted cancer therapy.
Keywords: Polysaccharide, cancer therapy, targeted delivery, targeted therapy, nanomedicine, biopolymer carrier.
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