Acanthamoeba Keratitis: Current Status and Urgent Research Priorities

Author(s): Naveed Ahmed Khan*, Ayaz Anwar, Ruqaiyyah Siddiqui.

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 30 , 2019

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Abstract:

Background: First discovered in the early 1970s, Acanthamoeba keratitis has remained a major eye infection and presents a significant threat to the public health, especially in developing countries. The aim is to present a timely review of our current understanding of the advances made in this field in a comprehensible manner and includes novel concepts and provides clear directions for immediate research priorities.

Methods: We undertook a search of bibliographic databases for peer-reviewed research literature and also summarized our published results in this field.

Results: The present review focuses on novel diagnostic and therapeutic strategies in details which can provide access to management and treatment of Acanthamoeba keratitis. This coupled with the recently available genome sequence information together with high throughput genomics technology and innovative approaches should stimulate interest in the rational design of preventative and therapeutic measures. Current treatment of Acanthamoeba keratitis is problematic and often leads to infection recurrence. Better understanding of diagnosis, pathogenesis, pathophysiology and therapeutic regimens, would lead to novel strategies in treatment and prophylaxis.

Keywords: Parasite, cornea, pathogenesis, nanotechnology, inflammation, blindness.

[1]
Visvesvara, G.S. Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment. Curr. Opin. Infect. Dis., 2010, 23(6), 590-594.
[http://dx.doi.org/10.1097/QCO.0b013e32833ed78b] [PMID: 20802332]
[2]
Dart, J.K.; Saw, V.P.; Kilvington, S. Acanthamoeba keratitis: diagnosis and treatment update 2009. Am. J. Ophthalmol., 2009, 148(4), 487-499.e2.
[http://dx.doi.org/10.1016/j.ajo.2009.06.009] [PMID: 19660733]
[3]
Khan, N.A. Acanthamoeba: Biology and Pathogenesis, 2nd ed; Caister Academic Press: UK, 2015, p. 344.
[4]
Marciano-Cabral, F.; Cabral, G. Acanthamoeba spp. as agents of disease in humans. Clin. Microbiol. Rev., 2003, 16(2), 273-307.
[http://dx.doi.org/10.1128/CMR.16.2.273-307.2003] [PMID: 12692099]
[5]
Radford, C.F.; Minassian, D.C.; Dart, J.K. Acanthamoeba keratitis in England and Wales: incidence, outcome, and risk factors. Br. J. Ophthalmol., 2002, 86(5), 536-542.
[http://dx.doi.org/10.1136/bjo.86.5.536] [PMID: 11973250]
[6]
Seal, D.V.; Kirkness, C.M.; Bennett, H.G.B.; Peterson, M. Keratitis study group Population-based cohort study of microbial keratitis in Scotland: incidence and features. Cont. Lens Anterior Eye, 1999, 22(2), 49-57.
[http://dx.doi.org/10.1016/S1367-0484(99)80003-4] [PMID: 16303406]
[7]
Thebpatiphat, N.; Hammersmith, K.M.; Rocha, F.N.; Rapuano, C.J.; Ayres, B.D.; Laibson, P.R.; Eagle, R.C., Jr; Cohen, E.J. Acanthamoeba keratitis: a parasite on the rise. Cornea, 2007, 26(6), 701-706.
[http://dx.doi.org/10.1097/ICO.0b013e31805b7e63] [PMID: 17592320]
[8]
Patel, D.V.; Rayner, S.; McGhee, C.N. Resurgence of Acanthamoeba keratitis in Auckland, New Zealand: a 7-year review of presentation and outcomes. Clin. Exp. Ophthalmol., 2010, 38(1), 15-20.
[http://dx.doi.org/10.1111/j.1442-9071.2009.02182.x] [PMID: 20447096]
[9]
Carvalho, F.R.; Foronda, A.S.; Mannis, M.J.; Höfling-Lima, A.L.; Belfort, R., Jr; de Freitas, D. Twenty years of Acanthamoeba keratitis. Cornea, 2009, 28(5), 516-519.
[http://dx.doi.org/10.1097/ICO.0b013e318193e0fe] [PMID: 19421047]
[10]
Fraser, M.N.; Wong, Q.; Shah, L.; Holland, S.P.; Morshed, M.; Isaac-Renton, J.; Chong, M.; Kibsey, P.; Patrick, D.M. Characteristics of an Acanthamoeba keratitis outbreak in British Columbia between 2003 and 2007. Ophthalmology, 2012, 119(6), 1120-1125.
[http://dx.doi.org/10.1016/j.ophtha.2011.12.041] [PMID: 22365067]
[11]
Page, M.A.; Mathers, W.D. Acanthamoeba keratitis: a 12-year experience covering a wide spectrum of presentations, diagnoses, and outcomes. J. Ophthalmol., 2013.2013670242
[http://dx.doi.org/10.1155/2013/670242] [PMID: 23840938]
[12]
Yoder, J.S.; Verani, J.; Heidman, N.; Hoppe-Bauer, J.; Alfonso, E.C.; Miller, D.; Jones, D.B.; Bruckner, D.; Langston, R.; Jeng, B.H.; Joslin, C.E.; Tu, E.; Colby, K.; Vetter, E.; Ritterband, D.; Mathers, W.; Kowalski, R.P.; Acharya, N.R.; Limaye, A.P.; Leiter, C.; Roy, S.; Lorick, S.; Roberts, J.; Beach, M.J. Acanthamoeba keratitis: the persistence of cases following a multistate outbreak. Ophthalmic Epidemiol., 2012, 19(4), 221-225.
[http://dx.doi.org/10.3109/09286586.2012.681336] [PMID: 22775278]
[13]
Barr, J. 2004 Annual Report. Contact Lens Spectr., (January), 2005.
[14]
Cope, J.R.; Collier, S.A.; Rao, M.M.; Chalmers, R.; Mitchell, G.L.; Richdale, K.; Wagner, H.; Kinoshita, B.T.; Lam, D.Y.; Sorbara, L.; Zimmerman, A.; Yoder, J.S.; Beach, M.J. Contact lens wearer demographics and risk behaviors for contact lens-related eye infections - United States, 2014. MMWR Morb. Mortal. Wkly. Rep., 2015, 64(32), 865-870.
[http://dx.doi.org/10.15585/mmwr.mm6432a2] [PMID: 26292204]
[15]
Garate, M.; Marchant, J.; Cubillos, I.; Cao, Z.; Khan, N.A.; Panjwani, N. In vitro pathogenicity of Acanthamoeba is associated with the expression of the mannose-binding protein. Invest. Ophthalmol. Vis. Sci., 2006, 47(3), 1056-1062.
[http://dx.doi.org/10.1167/iovs.05-0477] [PMID: 16505041]
[16]
Rocha-Azevedo, B.D.; Jamerson, M.; Cabral, G.A.; Silva-Filho, F.C.; Marciano-Cabral, F. Acanthamoeba interaction with extracellular matrix glycoproteins: biological and biochemical characterization and role in cytotoxicity and invasiveness. J. Eukaryot. Microbiol., 2009, 56(3), 270-278.
[http://dx.doi.org/10.1111/j.1550-7408.2009.00399.x] [PMID: 19527355]
[17]
Clarke, D.W.; Alizadeh, H.; Niederkorn, J.Y. Failure of Acanthamoeba castellanii to produce intraocular infections. Invest. Ophthalmol. Vis. Sci., 2005, 46(7), 2472-2478.
[http://dx.doi.org/10.1167/iovs.05-0140] [PMID: 15980238]
[18]
Cruzat, A.; Witkin, D.; Baniasadi, N.; Zheng, L.; Ciolino, J.B.; Jurkunas, U.V.; Chodosh, J.; Pavan-Langston, D.; Dana, R.; Hamrah, P. Inflammation and the nervous system: the connection in the cornea in patients with infectious keratitis. Invest. Ophthalmol. Vis. Sci., 2011, 52(8), 5136-5143.
[http://dx.doi.org/10.1167/iovs.10-7048] [PMID: 21460259]
[19]
Panjwani, N. Pathogenesis of Acanthamoeba keratitis. Ocul. Surf., 2010, 8(2), 70-79.
[http://dx.doi.org/10.1016/S1542-0124(12)70071-X] [PMID: 20427010]
[20]
Clarke, D.W.; Niederkorn, J.Y. The pathophysiology of Acanthamoeba keratitis. Trends Parasitol., 2006, 22(4), 175-180.
[http://dx.doi.org/10.1016/j.pt.2006.02.004] [PMID: 16500148]
[21]
Stothard, D.R.; Schroeder-Diedrich, J.M.; Awwad, M.H.; Gast, R.J.; Ledee, D.R.; Rodriguez-Zaragoza, S.; Dean, C.L.; Fuerst, P.A.; Byers, T.J. The evolutionary history of the genus Acanthamoeba and the identification of eight new 18S rRNA gene sequence types. J. Eukaryot. Microbiol., 1998, 45(1), 45-54.
[http://dx.doi.org/10.1111/j.1550-7408.1998.tb05068.x] [PMID: 9495032]
[22]
Adamska, M. Molecular characterization of Acanthamoeba spp. occurring in water bodies and patients in Poland and redefinition of Polish T16 genotype. J. Eukaryot. Microbiol., 2016, 63(2), 262-270.
[http://dx.doi.org/10.1111/jeu.12275] [PMID: 26542537]
[23]
Maciver, S.K.; Asif, M.; Simmen, M.W.; Lorenzo-Morales, J. A systematic analysis of Acanthamoeba genotype frequency correlated with source and pathogenicity: T4 is confirmed as a pathogen-rich genotype. Eur. J. Protistol., 2013, 49(2), 217-221.
[http://dx.doi.org/10.1016/j.ejop.2012.11.004] [PMID: 23290304]
[24]
Ren, M.; Gao, L.; Wu, X. TLR4: the receptor bridging Acanthamoeba challenge and intracellular inflammatory responses in human corneal cell lines. Immunol. Cell Biol., 2010, 88(5), 529-536.
[http://dx.doi.org/10.1038/icb.2010.6] [PMID: 20125114]
[25]
Ren, M.Y.; Wu, X.Y. Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba keratitis. Parasite Immunol., 2011, 33(1), 25-33.
[http://dx.doi.org/10.1111/j.1365-3024.2010.01247.x] [PMID: 21155840]
[26]
Sissons, J.; Alsam, S.; Jayasekera, S.; Kim, K.S.; Stins, M.; Khan, N.A. Acanthamoeba induces cell-cycle arrest in host cells. J. Med. Microbiol., 2004, 53(Pt 8), 711-717.
[http://dx.doi.org/10.1099/jmm.0.45604-0] [PMID: 15272056]
[27]
Sissons, J.; Kim, K.S.; Stins, M.; Jayasekera, S.; Alsam, S.; Khan, N.A. Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism. Infect. Immun., 2005, 73(5), 2704-2708.
[http://dx.doi.org/10.1128/IAI.73.5.2704-2708.2005] [PMID: 15845472]
[28]
Chusattayanond, A.D.; Boonsilp, S.; Kasisit, J.; Boonmee, A.; Warit, S. Thai Acanthamoeba isolate (T4) induced apoptotic death in neuroblastoma cells via the Bax-mediated pathway. Parasitol. Int., 2010, 59(4), 512-516.
[http://dx.doi.org/10.1016/j.parint.2010.06.007] [PMID: 20601106]
[29]
Tripathi, T.; Abdi, M.; Alizadeh, H. Role of phospholipase A2 (PLA2) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis. Exp. Eye Res., 2013, 113, 182-191.
[http://dx.doi.org/10.1016/j.exer.2013.05.021] [PMID: 23792108]
[30]
Niederkorn, J.Y.; Alizadeh, H.; Leher, H.; McCulley, J.P. The pathogenesis of Acanthamoeba keratitis. Microbes Infect., 1999, 1(6), 437-443.
[http://dx.doi.org/10.1016/S1286-4579(99)80047-1] [PMID: 10602676]
[31]
Taylor, W.M.; Pidherney, M.S.; Alizadeh, H.; Niederkorn, J.Y. In vitro characterization of Acanthamoeba castellanii cytopathic effect. J. Parasitol., 1995, 81(4), 603-609.
[http://dx.doi.org/10.2307/3283860] [PMID: 7623204]
[32]
Siddiqui, R.; Iqbal, J.; Maugueret, M.J.; Khan, N.A. The role of Src kinase in the biology and pathogenesis of Acanthamoeba castellanii. Parasit. Vectors, 2012, 5, 112.
[http://dx.doi.org/10.1186/1756-3305-5-112] [PMID: 22676352]
[33]
Hurt, M.; Neelam, S.; Niederkorn, J.; Alizadeh, H. Pathogenic Acanthamoeba spp secrete a mannose-induced cytolytic protein that correlates with the ability to cause disease. Infect. Immun., 2003, 71(11), 6243-6255.
[http://dx.doi.org/10.1128/IAI.71.11.6243-6255.2003] [PMID: 14573643]
[34]
Cao, Z.; Jefferson, D.M.; Panjwani, N. Role of carbohydrate-mediated adherence in cytopathogenic mechanisms of Acanthamoeba. J. Biol. Chem., 1998, 273(25), 15838-15845.
[http://dx.doi.org/10.1074/jbc.273.25.15838] [PMID: 9624184]
[35]
Victoria, E.J.; Korn, E.D. Enzymes of phospholipid metabolism in the plasma membrane of Acanthamoeba castellanii. J. Lipid Res., 1975, 16(1), 54-60.
[PMID: 1110322]
[36]
Mortazavi, P.N.; Keisary, E.; Loh, L.N.; Jung, S.Y.; Khan, N.A. Possible roles of phospholipase A(2) in the biological activities of Acanthamoeba castellanii (T4 Genotype). Protist, 2011, 162(1), 168-176.
[http://dx.doi.org/10.1016/j.protis.2010.03.005] [PMID: 20650684]
[37]
Lynch, T.J.; Albanesi, J.P.; Korn, E.D.; Robinson, E.A.; Bowers, B.; Fujisaki, H. ATPase activities and actin-binding properties of subfragments of Acanthamoeba myosin IA. J. Biol. Chem., 1986, 261(36), 17156-17162.
[PMID: 2946692]
[38]
Sissons, J.; Alsam, S.; Jayasekera, S.; Khan, N.A. Ecto-ATPases of clinical and non-clinical isolates of Acanthamoeba. Microb. Pathog., 2004, 37(5), 231-239.
[http://dx.doi.org/10.1016/j.micpath.2004.01.004] [PMID: 15519044]
[39]
Pellegrin, J.L.; Ortega-Barria, E.; Barza, M.; Baum, J.; Pereira, M.E. Neuraminidase activity in acanthamoeba species trophozoites and cysts. Invest. Ophthalmol. Vis. Sci., 1991, 32(12), 3061-3066.
[PMID: 1938282]
[40]
Choi, D.H.; Na, B.K.; Seo, M.S.; Song, H.R.; Song, C.Y. Purification and characterization of iron superoxide dismutase and copper-zinc superoxide dismutase from Acanthamoeba castellanii. J. Parasitol., 2000, 86(5), 899-907.
[http://dx.doi.org/10.2307/3284795] [PMID: 11128508]
[41]
Kim, J.Y.; Na, B.K.; Song, K.J.; Park, M.H.; Park, Y.K.; Kim, T.S. Functional expression and characterization of an iron-containing superoxide dismutase of Acanthamoeba castellanii. Parasitol. Res., 2012, 111(4), 1673-1682.
[http://dx.doi.org/10.1007/s00436-012-3006-7] [PMID: 22752747]
[42]
Ferrante, A.; Bates, E.J. Elastase in the pathogenic free-living amoebae Naegleria and Acanthamoeba spp. Infect. Immun., 1988, 56(12), 3320-3321.
[PMID: 3182083]
[43]
Ferreira, G.A.; Magliano, A.C.; Pral, E.M.; Alfieri, S.C. Elastase secretion in Acanthamoeba polyphaga. Acta Trop., 2009, 112(2), 156-163.
[http://dx.doi.org/10.1016/j.actatropica.2009.07.015] [PMID: 19632188]
[44]
Rosenthal, S.; Reed, E.J.; Weisman, R.A. Effect of lytic enzymes of Acanthamoeba castellanii on bacterial cell walls. J. Bacteriol., 1969, 98(1), 182-189.
[PMID: 5781574]
[45]
Weisman, R.A.; Spiegel, R.S.; McCauley, J.G. Differentiation in acanthamoeba: glycogen levels and glycogen synthetase activity during encystment. Biochim. Biophys. Acta, 1970, 201(1), 45-53.
[http://dx.doi.org/10.1016/0304-4165(70)90008-5] [PMID: 5412510]
[46]
Michalek, M.; Sönnichsen, F.D.; Wechselberger, R.; Dingley, A.J.; Hung, C.W.; Kopp, A.; Wienk, H.; Simanski, M.; Herbst, R.; Lorenzen, I.; Marciano-Cabral, F.; Gelhaus, C.; Gutsmann, T.; Tholey, A.; Grötzinger, J.; Leippe, M. Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba. Nat. Chem. Biol., 2013, 9(1), 37-42.
[http://dx.doi.org/10.1038/nchembio.1116] [PMID: 23143413]
[47]
Na, B.K.; Cho, J.H.; Song, C.Y.; Kim, T.S. Degradation of immunoglobulins, protease inhibitors and interleukin-1 by a secretory proteinase of Acanthamoeba castellanii. Korean J. Parasitol., 2002, 40(2), 93-99.
[http://dx.doi.org/10.3347/kjp.2002.40.2.93] [PMID: 12073735]
[48]
Toney, D.M.; Marciano-Cabral, F. Resistance of Acanthamoeba species to complement lysis. J. Parasitol., 1998, 84(2), 338-344.
[http://dx.doi.org/10.2307/3284492] [PMID: 9576508]
[49]
McClellan, K.; Howard, K.; Mayhew, E.; Niederkorn, J.; Alizadeh, H. Adaptive immune responses to Acanthamoeba cysts. Exp. Eye Res., 2002, 75(3), 285-293.
[http://dx.doi.org/10.1006/exer.2002.2015] [PMID: 12384091]
[50]
Harrison, J.L.; Ferreira, G.A.; Raborn, E.S.; Lafrenaye, A.D.; Marciano-Cabral, F.; Cabral, G.A. Acanthamoeba culbertsoni elicits soluble factors that exert anti-microglial cell activity. Infect. Immun., 2010, 78(9), 4001-4011.
[http://dx.doi.org/10.1128/IAI.00047-10] [PMID: 20605979]
[51]
Turner, N.A.; Russell, A.D.; Furr, J.R.; Lloyd, D. Emergence of resistance to biocides during differentiation of Acanthamoeba castellanii. J. Antimicrob. Chemother., 2000, 46(1), 27-34.
[http://dx.doi.org/10.1093/jac/46.1.27] [PMID: 10882685]
[52]
Turner, N.A.; Russell, A.D.; Furr, J.R.; Lloyd, D. Resistance, biguanide sorption and biguanide-induced pentose leakage during encystment of Acanthamoeba castellanii. J. Appl. Microbiol., 2004, 96(6), 1287-1295.
[http://dx.doi.org/10.1111/j.1365-2672.2004.02260.x] [PMID: 15139921]
[53]
Pettit, D.A.; Williamson, J.; Cabral, G.A.; Marciano-Cabral, F. In vitro destruction of nerve cell cultures by Acanthamoeba spp.: a transmission and scanning electron microscopy study. J. Parasitol., 1996, 82(5), 769-777.
[http://dx.doi.org/10.2307/3283890] [PMID: 8885887]
[54]
Byers, T.J.; Kim, B.G.; King, L.E.; Hugo, E.R. Molecular aspects of the cell cycle and encystment of Acanthamoeba. Rev. Infect. Dis., 1991, 13(Suppl. 5), S373-S384.
[http://dx.doi.org/10.1093/clind/13.Supplement_5.S373] [PMID: 2047666]
[55]
Aksozek, A.; McClellan, K.; Howard, K.; Niederkorn, J.Y.; Alizadeh, H. Resistance of Acanthamoeba castellanii cysts to physical, chemical, and radiological conditions. J. Parasitol, 2002, 88(3), 621>-623.
[http://dx.doi.org/10.1645/0022- 3395(2002)088[0621:ROACCT]2.0.CO;2] [PMID: 12099437]
[56]
Mazur, T.; Hadaś, E.; Iwanicka, I. The duration of the cyst stage and the viability and virulence of Acanthamoeba isolates. Trop. Med. Parasitol., 1995, 46(2), 106-108.
[PMID: 8525280]
[57]
Sriram, R.; Shoff, M.; Booton, G.; Fuerst, P.; Visvesvara, G.S. Survival of Acanthamoeba cysts after desiccation for more than 20 years. J. Clin. Microbiol., 2008, 46(12), 4045-4048.
[http://dx.doi.org/10.1128/JCM.01903-08] [PMID: 18923013]
[58]
Kal, A.; Toker, M.I.; Kaya, S. The comparison of antimicrobial effectiveness of contact lens solutions. Int. Ophthalmol., 2016.
[PMID: 27738866]
[59]
de Aguiar, A.P.; de Oliveira Silveira, C.; Todero Winck, M.A.; Rott, M.B. Susceptibility of Acanthamoeba to multipurpose lens-cleaning solutions. Acta Parasitol., 2013, 58(3), 304-308.
[http://dx.doi.org/10.2478/s11686-013-0143-9] [PMID: 23990426]
[60]
Gomes, Tdo. S.; Magnet, A.; Izquierdo, F.; Vaccaro, L.; Redondo, F.; Bueno, S.; Sánchez, M.L.; Angulo, S.; Fenoy, S.; Hurtado, C.; Del Aguila, C. Acanthamoeba spp. in contact lenses from healthy individuals from Madrid, Spain. PLoS One, 2016, 11(4)e0154246
[http://dx.doi.org/10.1371/journal.pone.0154246] [PMID: 27105183]
[61]
Weisman, R.A. Differentiation in Acanthamoeba castellanii. Annu. Rev. Microbiol., 1976, 30, 189-219.
[http://dx.doi.org/10.1146/annurev.mi.30.100176.001201] [PMID: 791066]
[62]
Dudley, R.; Jarroll, E.L.; Khan, N.A. Carbohydrate analysis of Acanthamoeba castellanii. Exp. Parasitol., 2009, 122(4), 338-343.
[http://dx.doi.org/10.1016/j.exppara.2009.04.009] [PMID: 19389397]
[63]
Casemore, D.P. Sensitivity of Hartmannella (Acanthamoeba) to 5-fluorocytosine, hydroxystilbamidine, and other substances. J. Clin. Pathol., 1970, 23(8), 649-652.
[http://dx.doi.org/10.1136/jcp.23.8.649] [PMID: 5536863]
[64]
Nagington, J.; Richards, J.E. Chemotherapeutic compounds and Acanthamoebae from eye infections. J. Clin. Pathol., 1976, 29(7), 648-651.
[http://dx.doi.org/10.1136/jcp.29.7.648] [PMID: 185240]
[65]
Ficker, L.; Seal, D.; Warhurst, D.; Wright, P. Acanthamoeba keratitis--resistance to medical therapy. Eye (Lond.), 1990, 4(Pt 6), 835-838.
[http://dx.doi.org/10.1038/eye.1990.132] [PMID: 2101116]
[66]
Hay, J.; Kirkness, C.M.; Seal, D.V.; Wright, P. Drug resistance and Acanthamoeba keratitis: the quest for alternative antiprotozoal chemotherapy. Eye (Lond.), 1994, 8(Pt 5), 555-563.
[http://dx.doi.org/10.1038/eye.1994.137] [PMID: 7835453]
[67]
Hargrave, S.L.; McCulley, J.P.; Husseini, Z. Brolene Study Group Results of a trial of combined propamidine isethionate and neomycin therapy for Acanthamoeba keratitis. Ophthalmology, 1999, 106(5), 952-957.
[http://dx.doi.org/10.1016/S0161-6420(99)00515-1] [PMID: 10328395]
[68]
Ondarza, R.N.; Iturbe, A.; Hernández, E. In vitro antiproliferative effects of neuroleptics, antimycotics and antibiotics on the human pathogens Acanthamoeba polyphaga and Naegleria fowleri. Arch. Med. Res., 2006, 37(6), 723-729.
[http://dx.doi.org/10.1016/j.arcmed.2006.02.007] [PMID: 16824931]
[69]
Maurin, M.; Bryskier, A.; Raoult, D. Antibiotic susceptibilities of Parachlamydia acanthamoeba in amoebae. Antimicrob. Agents Chemother., 2002, 46(9), 3065-3067.
[http://dx.doi.org/10.1128/AAC.46.9.3065-3067.2002] [PMID: 12183273]
[70]
Noradilah, S.A.; Kamel, A.M.; Anisah, N.; Noraina, A.R.; Yusof, S. The effectiveness of gentamicin against Acanthamoeba cysts in vitro. Malaysian J. Med. Health Sci., 2012, 8, 51-54.
[71]
Wright, P.; Warhurst, D.; Jones, B.R. Acanthamoeba keratitis successfully treated medically. Br. J. Ophthalmol., 1985, 69(10), 778-782.
[http://dx.doi.org/10.1136/bjo.69.10.778] [PMID: 4052364]
[72]
Kilvington, S.; Price, J. Survival of Legionella pneumophila within cysts of Acanthamoeba polyphaga following chlorine exposure. J. Appl. Bacteriol., 1990, 68(5), 519-525.
[http://dx.doi.org/10.1111/j.1365-2672.1990.tb02904.x] [PMID: 2196257]
[73]
Perrine, D.; Barbier, D.; Georges, P. [Comparative in vitro activity of chlorine and bromine on the cysts of free-living amoebae] C. R. Seances Soc. Biol. Fil., 1980, 174(3), 297-303.
[PMID: 6448673]
[74]
Radford, C.F.; Bacon, A.S.; Dart, J.K.; Minassian, D.C. Risk factors for Acanthamoeba keratitis in contact lens users: a case-control study. BMJ, 1995, 310(6994), 1567-1570.
[http://dx.doi.org/10.1136/bmj.310.6994.1567] [PMID: 7787645]
[75]
Lin, M.C.; Polse, K.A. Hypoxia, overnight wear, and tear stagnation effects on the corneal epithelium: data and proposed model. Eye Contact Lens, 2007, 33(6 Pt 2), 378-381.
[http://dx.doi.org/10.1097/ICL.0b013e318157d7c9] [PMID: 17975425]
[76]
Moore, M.B. Acanthamoeba keratitis and contact lens wear: the patient is at fault. Cornea, 1990, 9(Suppl. 1), S33-S35.
[http://dx.doi.org/10.1097/00003226-199010001-00014] [PMID: 2189677]
[77]
Lakhundi, S.; Khan, N.A.; Siddiqui, R. Inefficacy of marketed contact lens disinfection solutions against keratitis-causing Acanthamoeba castellanii belonging to the T4 genotype. Exp. Parasitol., 2014, 141, 122-128.
[http://dx.doi.org/10.1016/j.exppara.2014.03.018] [PMID: 24657584]
[78]
Kaji, Y.; Hu, B.; Kawana, K.; Oshika, T. Swimming with soft contact lenses: danger of Acanthamoeba keratitis. Lancet Infect. Dis., 2005, 5(6), 392.
[http://dx.doi.org/10.1016/S1473-3099(05)70143-2] [PMID: 15919625]
[79]
Prajna, N.V.; Pillai, M.R.; Manimegalai, T.K.; Srinivasan, M. Use of traditional eye medicines by corneal ulcer patients presenting to a hospital in South India. Indian J. Ophthalmol., 1999, 47(1), 15-18.
[PMID: 16130279]
[80]
Osahon, A.I. Consequences of traditional eye medication in U.B.T.H., Benin City. Nigerian J. Ophthalmol., 1995, 3, 51-54.
[81]
van Klink, F.; Taylor, W.M.; Alizadeh, H.; Jager, M.J.; van Rooijen, N.; Niederkorn, J.Y. The role of macrophages in Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci., 1996, 37(7), 1271-1281.
[PMID: 8641830]
[82]
Hurt, M.; Apte, S.; Leher, H.; Howard, K.; Niederkorn, J.; Alizadeh, H. Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies. Infect. Immun., 2001, 69(5), 2988-2995.
[http://dx.doi.org/10.1128/IAI.69.5.2988-2995.2001] [PMID: 11292716]
[83]
Hurt, M.; Proy, V.; Niederkorn, J.Y.; Alizadeh, H. The interaction of Acanthamoeba castellanii cysts with macrophages and neutrophils. J. Parasitol, 2003, 89(3), 565-572.
[http://dx.doi.org/10.1645/0022- 3395(2003)089[0565:TIOACC]2.0.CO;2] [PMID: 12880257]
[84]
Pan, H.; Wu, X. Hypoxia attenuates inflammatory mediators production induced by Acanthamoeba via Toll-like receptor 4 signaling in human corneal epithelial cells. Biochem. Biophys. Res. Commun., 2012, 420(3), 685-691.
[http://dx.doi.org/10.1016/j.bbrc.2012.03.069] [PMID: 22450324]
[85]
Thakur, A.; Willcox, M.D. Contact lens wear alters the production of certain inflammatory mediators in tears. Exp. Eye Res., 2000, 70(3), 255-259.
[http://dx.doi.org/10.1006/exer.1999.0767] [PMID: 10712811]
[86]
Walochnik, J.; Obwaller, A.; Haller-Schober, E.M.; Aspöck, H. Anti-Acanthamoeba IgG, IgM, and IgA immunoreactivities in correlation to strain pathogenicity. Parasitol. Res., 2001, 87(8), 651-656.
[http://dx.doi.org/10.1007/s004360100412] [PMID: 11511003]
[87]
Devonshire, P.; Munro, F.A.; Abernethy, C.; Clark, B.J. Microbial contamination of contact lens cases in the west of Scotland. Br. J. Ophthalmol., 1993, 77(1), 41-45.
[http://dx.doi.org/10.1136/bjo.77.1.41] [PMID: 8435399]
[88]
Larkin, D.F.; Kilvington, S.; Easty, D.L. Contamination of contact lens storage cases by Acanthamoeba and bacteria. Br. J. Ophthalmol., 1990, 74(3), 133-135.
[http://dx.doi.org/10.1136/bjo.74.3.133] [PMID: 2322508]
[89]
Gray, T.B.; Gross, K.A.; Cursons, R.T.; Shewan, J.F. Acanthamoeba keratitis: a sobering case and a promising new treatment. Aust. N. Z. J. Ophthalmol., 1994, 22(1), 73-76.
[http://dx.doi.org/10.1111/j.1442-9071.1994.tb01700.x] [PMID: 8037919]
[90]
Tachikawa, T.; Ishibashi, Y.; Fujisawa, S.; Takazawa, S.; Nyunt, A.K.; Miyanaga, Y. A nation-wide survey on the occurrence of amoebic keratitis in Japan. Nippon Ganka Gakkai Zasshi, 1995, 99(1), 68-75.
[PMID: 7887330]
[91]
Sharma, S.; Garg, P.; Rao, G.N. Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis. Br. J. Ophthalmol., 2000, 84(10), 1103-1108.
[http://dx.doi.org/10.1136/bjo.84.10.1103] [PMID: 11004092]
[92]
Siddiqui, R.; Chaudhry, T.; Lakhundi, S.; Ahmad, K.; Khan, N.A. Failure of chemotherapy in the first reported cases of Acanthamoeba keratitis in Pakistan. Pathog. Glob. Health, 2014, 108(1), 49-52.
[http://dx.doi.org/10.1179/2047773213Y.0000000124] [PMID: 24548160]
[93]
Riaz, Q.; Fawwad, U.; Bhatti, N.; Rehman, A.; Hasan, M. Epidemiology of microbial keratitis in a tertiary care center in Karachi. Pak. J. Ophthalmol., 2013, 29, 2.
[94]
Horsburgh, B.; Hirst, L.W.; Carey, T.; Whitby, R.M.; Nimmo, G.; Stallard, K. Steroid sensitive Acanthamoeba keratitis. Aust. N. Z. J. Ophthalmol., 1991, 19(4), 349-350.
[http://dx.doi.org/10.1111/j.1442-9071.1991.tb00684.x] [PMID: 1789976]
[95]
Alizadeh, H.; Li, H.; Neelam, S.; Niederkorn, J.Y. Modulation of corneal and stromal matrix metalloproteinase by the mannose-induced Acanthamoeba cytolytic protein. Exp. Eye Res., 2008, 87(3), 286-291.
[http://dx.doi.org/10.1016/j.exer.2008.06.011] [PMID: 18627771]
[96]
Qu, X.D.; Lehrer, R.I. Secretory phospholipase A2 is the principal bactericide for Staphylococci and other gram-positive bacteria in human tears. Infect. Immun., 1998, 66(6), 2791-2797.
[PMID: 9596749]
[97]
Cao, Z.; Saravanan, C.; Goldstein, M.H.; Wu, H.K.; Pasricha, G.; Sharma, S.; Panjwani, N. Effect of human tears on acanthamoeba-induced cytopathic effect. Arch. Ophthalmol., 2008, 126(3), 348-352.
[http://dx.doi.org/10.1001/archophthalmol.2007.74] [PMID: 18332314]
[98]
Alsam, S.; Jeong, S.R.; Dudley, R.; Khan, N.A. Role of human tear fluid in Acanthamoeba interactions with the human corneal epithelial cells. Int. J. Med. Microbiol., 2008, 298(3-4), 329-336.
[http://dx.doi.org/10.1016/j.ijmm.2007.05.010] [PMID: 17931971]
[99]
Kijlstra, A.; Kuizenga, A. Analysis and function of the human tear proteins. Adv. Exp. Med. Biol., 1994, 350, 299-308.
[http://dx.doi.org/10.1007/978-1-4615-2417-5_51] [PMID: 8030492]
[100]
Otri, A.M.; Mohammed, I.; Abedin, A.; Cao, Z.; Hopkinson, A.; Panjwani, N.; Dua, H.S. Antimicrobial peptides expression by ocular surface cells in response to Acanthamoeba castellanii: an in vitro study. Br. J. Ophthalmol., 2010, 94(11), 1523-1527.
[http://dx.doi.org/10.1136/bjo.2009.178236] [PMID: 20679078]
[101]
Chintakuntlawar, A.V.; Chodosh, J. Cellular and tissue architecture of conjunctival membranes in epidemic keratoconjunctivitis. Ocul. Immunol. Inflamm., 2010, 18(5), 341-345.
[http://dx.doi.org/10.3109/09273948.2010.498658] [PMID: 20735288]
[102]
Rezaei Kanavi, M.; Naghshgar, N.; Javadi, M.A.; Sadat Hashemi, M. Various confocal scan features of cysts and trophozoites in cases with Acanthamoeba keratitis. Eur. J. Ophthalmol., 2012, 22(Suppl. 7), S46-S50.
[http://dx.doi.org/10.5301/ejo.5000139] [PMID: 22427148]
[103]
Vaddavalli, P.K.; Garg, P.; Sharma, S.; Sangwan, V.S.; Rao, G.N.; Thomas, R. Role of confocal microscopy in the diagnosis of fungal and Acanthamoeba keratitis. Ophthalmology, 2011, 118(1), 29-35.
[http://dx.doi.org/10.1016/j.ophtha.2010.05.018] [PMID: 20801515]
[104]
Epstein, R.J.; Wilson, L.A.; Visvesvara, G.S.; Plourde, E.G. Jr Rapid diagnosis of Acanthamoeba keratitis from corneal scrapings using indirect fluorescent antibody staining. Arch. Ophthalmol., 1986, 104(9), 1318-1321.
[http://dx.doi.org/10.1001/archopht.1986.01050210072028] [PMID: 2428344]
[105]
Khan, N.A.; Paget, T.A. Molecular tools for speciation and epidemiological studies of Acanthamoeba. Curr. Microbiol., 2002, 44(6), 444-449.
[http://dx.doi.org/10.1007/s00284-001-0050-4] [PMID: 12000996]
[106]
Schroeder, J.M.; Booton, G.C.; Hay, J.; Niszl, I.A.; Seal, D.V.; Markus, M.B.; Fuerst, P.A.; Byers, T.J. Use of subgenic 18S ribosomal DNA PCR and sequencing for genus and genotype identification of acanthamoebae from humans with keratitis and from sewage sludge. J. Clin. Microbiol., 2001, 39(5), 1903-1911.
[http://dx.doi.org/10.1128/JCM.39.5.1903-1911.2001] [PMID: 11326011]
[107]
Goldschmidt, P.; Degorge, S.; Benallaoua, D.; Batellier, L.; Di Cave, D.; Chaumeil, C. Rapid detection and simultaneous molecular profile characterization of Acanthamoeba infections. Diagn. Microbiol. Infect. Dis., 2012, 74(2), 137-141.
[http://dx.doi.org/10.1016/j.diagmicrobio.2012.06.001] [PMID: 22819239]
[108]
Ikeda, Y.; Miyazaki, D.; Yakura, K.; Kawaguchi, A.; Ishikura, R.; Inoue, Y.; Mito, T.; Shiraishi, A.; Ohashi, Y.; Higaki, S.; Itahashi, M.; Fukuda, M.; Shimomura, Y.; Yagita, K. Assessment of real-time polymerase chain reaction detection of Acanthamoeba and prognosis determinants of Acanthamoeba keratitis. Ophthalmology, 2012, 119(6), 1111-1119.
[http://dx.doi.org/10.1016/j.ophtha.2011.12.023] [PMID: 22381810]
[109]
Maubon, D.; Dubosson, M.; Chiquet, C.; Yera, H.; Brenier-Pinchart, M.P.; Cornet, M.; Savy, O.; Renard, E.; Pelloux, H. A one-step multiplex PCR for Acanthamoeba keratitis diagnosis and quality samples control. Invest. Ophthalmol. Vis. Sci., 2012, 53(6), 2866-2872.
[http://dx.doi.org/10.1167/iovs.11-8587] [PMID: 22427550]
[110]
Visvesvara, G.S.; Moura, H.; Schuster, F.L. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunol. Med. Microbiol., 2007, 50(1), 1-26.
[http://dx.doi.org/10.1111/j.1574-695X.2007.00232.x] [PMID: 17428307]
[111]
Ondarza, R.N.; Hernandez, E.; Hurtado, G.; Woolery, M.; Hernandez-Sandoval, F. Mass spectrometry characterization of trypanothione and novel peptides of medical importance isolated from Acanthamoeba polyphaga. Infect. Disord. Drug Targets, 2013, 13(2), 133-140.
[http://dx.doi.org/10.2174/18715265113139990023] [PMID: 23808873]
[112]
Zheng, L.; Wei, J.; Lv, X.; Bi, Y.; Wu, P.; Zhang, Z.; Wang, P.; Liu, R.; Jiang, J.; Cong, H.; Liang, J.; Chen, W.; Cao, H.; Liu, W.; Gao, G.F.; Du, Y.; Jiang, X.; Li, X. Detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles. Biosens. Bioelectron., 2017, 91, 46-52.
[http://dx.doi.org/10.1016/j.bios.2016.12.037] [PMID: 27987410]
[113]
Chen, W.; Li, Q.; Zheng, W.; Hu, F.; Zhang, G.; Wang, Z.; Zhang, D.; Jiang, X. Identification of bacteria in water by a fluorescent array. Angew. Chem. Int. Ed. Engl., 2014, 53(50), 13734-13739.
[http://dx.doi.org/10.1002/anie.201407606] [PMID: 25313526]
[114]
Chen, Y.; Xianyu, Y.; Wang, Y.; Zhang, X.; Cha, R.; Sun, J.; Jiang, X. One-step detection of pathogens and viruses: combining magnetic relaxation switching and magnetic separation. ACS Nano, 2015, 9(3), 3184-3191.
[http://dx.doi.org/10.1021/acsnano.5b00240] [PMID: 25743636]
[115]
Chen, Y.; Xianyu, Y.; Sun, J.; Niu, Y.; Wang, Y.; Jiang, X. One-step detection of pathogens and cancer biomarkers by the naked eye based on aggregation of immunomagnetic beads. Nanoscale, 2016, 8(2), 1100-1107.
[http://dx.doi.org/10.1039/C5NR07044A] [PMID: 26666198]
[116]
Chen, Y.; Sun, J.; Xianyu, Y.; Yin, B.; Niu, Y.; Wang, S.; Cao, F.; Zhang, X.; Wang, Y.; Jiang, X. A dual-readout chemiluminescent-gold lateral flow test for multiplex and ultrasensitive detection of disease biomarkers in real samples. Nanoscale, 2016, 8(33), 15205-15212.
[http://dx.doi.org/10.1039/C6NR04017A] [PMID: 27375054]
[117]
Abdul Khaliq, R.; Sonawane, P.J.; Sasi, B.K.; Sahu, B.S.; Pradeep, T.; Das, S.K.; Mahapatra, N.R. Enhancement in the efficiency of polymerase chain reaction by TiO2 nanoparticles: crucial role of enhanced thermal conductivity. Nanotechnology, 2010, 21(25)255704
[http://dx.doi.org/10.1088/0957-4484/21/25/255704] [PMID: 20516586]
[118]
Pérez-Santonja, J.J.; Kilvington, S.; Hughes, R.; Tufail, A.; Matheson, M.; Dart, J.K.G. Persistently culture positive Acanthamoeba keratitis: in vivo resistance and in vitro sensitivity. Ophthalmology, 2003, 110(8), 1593-1600.
[http://dx.doi.org/10.1016/S0161-6420(03)00481-0] [PMID: 12917179]
[119]
Bang, S.; Edell, E.; Eghrari, A.O.; Gottsch, J.D. Treatment with voriconazole in 3 eyes with resistant Acanthamoeba keratitis. Am. J. Ophthalmol., 2010, 149(1), 66-69.
[http://dx.doi.org/10.1016/j.ajo.2009.08.004] [PMID: 19875089]
[120]
Tu, E.Y.; Joslin, C.E.; Shoff, M.E. Successful treatment of chronic stromal Acanthamoeba keratitis with oral voriconazole monotherapy. Cornea, 2010, 29(9), 1066-1068.
[http://dx.doi.org/10.1097/ICO.0b013e3181cbfa2c] [PMID: 20539217]
[121]
Sun, X.; Zhang, Y.; Li, R.; Wang, Z.; Luo, S.; Gao, M.; Deng, S.; Chen, W.; Jin, X. Acanthamoeba keratitis: clinical characteristics and management. Ophthalmology, 2006, 113(3), 412-416.
[http://dx.doi.org/10.1016/j.ophtha.2005.10.041] [PMID: 16427699]
[122]
McClellan, K.; Howard, K.; Niederkorn, J.Y.; Alizadeh, H. Effect of steroids on Acanthamoeba cysts and trophozoites. Invest. Ophthalmol. Vis. Sci., 2001, 42(12), 2885-2893.
[PMID: 11687533]
[123]
Kelley, P.S.; Dossey, A.P.; Patel, D.; Whitson, J.T.; Hogan, R.N.; Cavanagh, H.D. Secondary glaucoma associated with advanced Acanthamoeba keratitis. Eye Contact Lens, 2006, 32(4), 178-182.
[http://dx.doi.org/10.1097/01.icl.0000189039.68782.fe] [PMID: 16845263]
[124]
Tomita, M.; Shimmura, S.; Tsubota, K.; Shimazaki, J. Dacryoadenitis associated with Acanthamoeba keratitis. Arch. Ophthalmol., 2006, 124(9), 1239-1242.
[http://dx.doi.org/10.1001/archopht.124.9.1239] [PMID: 16966617]
[125]
Gooi, P.; Lee-Wing, M.; Brownstein, S.; El-Defrawy, S.; Jackson, W.B.; Mintsioulis, G. Acanthamoeba keratitis: persistent organisms without inflammation after 1 year of topical chlorhexidine. Cornea, 2008, 27(2), 246-248.
[http://dx.doi.org/10.1097/ICO.0b013e31815b82a2] [PMID: 18216589]
[126]
Li, M.L.; Shih, M.H.; Huang, F.C.; Tseng, S.H.; Chen, C.C. Treatment of early Acanthamoeba keratitis with alcohol-assisted epithelial debridement. Cornea, 2012, 31(4), 442-446.
[http://dx.doi.org/10.1097/ICO.0b013e31823f091a] [PMID: 22236786]
[127]
Polat, Z.A.; Obwaller, A.; Vural, A.; Walochnik, J. Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters. Parasitol. Res., 2012, 110(2), 515-520.
[http://dx.doi.org/10.1007/s00436-011-2515-0] [PMID: 21748351]
[128]
Gatti, S.; Cevini, C.; Bruno, A.; Penso, G.; Rama, P.; Scaglia, M. In vitro effectiveness of povidone-iodine on Acanthamoeba isolates from human cornea. Antimicrob. Agents Chemother., 1998, 42(9), 2232-2234.
[http://dx.doi.org/10.1128/AAC.42.9.2232] [PMID: 9736540]
[129]
Binder, P.S. Cryotherapy for medically unresponsive acanthamoeba keratitis. Cornea, 1989, 8(2), 106-114.
[http://dx.doi.org/10.1097/00003226-198906000-00006] [PMID: 2653724]
[130]
Letsch, J.; Abou-Bacar, A.; Candolfi, E.; Bourcier, T.; Sauer, A. Evaluation of in vitro efficacy of combined riboflavin and ultraviolet-A (365 nm) for Acanthamoeba. J. Fr. Ophtalmol., 2015, 38(3), 213-219.
[http://dx.doi.org/10.1016/j.jfo.2014.09.013] [PMID: 25637236]
[131]
Hager, T.; Hasenfus, A.; Stachon, T.; Seitz, B.; Szentmáry, N. Crosslinking and corneal cryotherapy in Acanthamoeba keratitis -- a histological study. Graefes Arch. Clin. Exp. Ophthalmol., 2016, 254(1), 149-153.
[http://dx.doi.org/10.1007/s00417-015-3189-6] [PMID: 26483144]
[132]
Padzik, M.; Szaflik, J.P.; Izdebska, J.; Szostakowska, B.; Szaflik, J.; Chomicz, L. Acanthamoeba polyphaga strain – causative agent of vision-threatening keratitis uncommonly detected in Poland, susceptible in vitro to toyocamycin. Klin. Ocz. Acta Ophthalmol. Pol., 2017, 119, 77-82.
[133]
Chomicz, L.; Szaflik, J.P.; Padzik, M.; Izdebska, J. Acanthamoeba keratitis: The Emerging Vision-2 Threatening Corneal Disease ; Advances in Common Eye Infections, Intech, 2016, pp 99-120.
[134]
Cohen, E.J.; Parlato, C.J.; Arentsen, J.J.; Genvert, G.I.; Eagle, R.C., Jr; Wieland, M.R.; Laibson, P.R. Medical and surgical treatment of Acanthamoeba keratitis. Am. J. Ophthalmol., 1987, 103(5), 615-625.
[http://dx.doi.org/10.1016/S0002-9394(14)74320-X] [PMID: 3555095]
[135]
Ficker, L.A.; Kirkness, C.; Wright, P. Prognosis for keratoplasty in Acanthamoeba keratitis. Ophthalmology, 1993, 100(1), 105-110.
[http://dx.doi.org/10.1016/S0161-6420(93)31707-0] [PMID: 8433814]
[136]
Chew, H.F.; Yildiz, E.H.; Hammersmith, K.M.; Eagle, R.C., Jr; Rapuano, C.J.; Laibson, P.R.; Ayres, B.D.; Jin, Y.P.; Cohen, E.J. Clinical outcomes and prognostic factors associated with Acanthamoeba keratitis. Cornea, 2011, 30(4), 435-441.
[http://dx.doi.org/10.1097/ICO.0b013e3181ec905f] [PMID: 21045665]
[137]
Vajpayee, R.B.; Singhvi, A.; Sharma, N.; Sinha, R. Penetrating keratoplasty for perforated corneal ulcers: preservation of iris by corneal debulking. Cornea, 2006, 25(1), 44-46.
[http://dx.doi.org/10.1097/01.ico.0000177834.85507.28] [PMID: 16331040]
[138]
Sharma, N.; Sachdev, R.; Jhanji, V.; Titiyal, J.S.; Vajpayee, R.B. Therapeutic keratoplasty for microbial keratitis. Curr. Opin. Ophthalmol., 2010, 21(4), 293-300.
[PMID: 20531191]
[139]
Taenaka, N.; Fukuda, M.; Hibino, T.; Kato, Y.; Arimura, E.; Ishii, Y.; Shimomura, Y. Surgical therapies for Acanthamoeba keratitis by phototherapeutic keratectomy and deep lamellar keratoplasty. Cornea, 2007, 26(7), 876-879.
[http://dx.doi.org/10.1097/ICO.0b013e318074b385] [PMID: 17667628]
[140]
Parthasarathy, A.; Tan, D.T. Deep lamellar keratoplasty for Acanthamoeba keratitis. Cornea, 2007, 26(8), 1021-1023.
[http://dx.doi.org/10.1097/ICO.0b013e3181131ea9] [PMID: 17721312]
[141]
Anshu, A.; Parthasarathy, A.; Mehta, J.S.; Htoon, H.M.; Tan, D.T. Outcomes of therapeutic deep lamellar keratoplasty and penetrating keratoplasty for advanced infectious keratitis: a comparative study. Ophthalmology, 2009, 116(4), 615-623.
[http://dx.doi.org/10.1016/j.ophtha.2008.12.043] [PMID: 19243833]
[142]
Kaul, D.R.; Lowe, L.; Visvesvara, G.S.; Farmen, S.; Khaled, Y.A.; Yanik, G.A. Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole. Transpl. Infect. Dis., 2008, 10(6), 437-441.
[http://dx.doi.org/10.1111/j.1399-3062.2008.00335.x] [PMID: 18713138]
[143]
Lorenzo-Morales, J.; Kliescikova, J.; Martinez-Carretero, E.; De Pablos, L.M.; Profotova, B.; Nohynkova, E.; Osuna, A.; Valladares, B. Glycogen phosphorylase in Acanthamoeba spp.: determining the role of the enzyme during the encystment process using RNA interference. Eukaryot. Cell, 2008, 7(3), 509-517.
[http://dx.doi.org/10.1128/EC.00316-07] [PMID: 18223117]
[144]
Faber, K.; Zorzi, G.K.; Brazil, N.T.; Rott, M.B.; Teixeira, H.F. siRNA-loaded liposomes: Inhibition of encystment of Acanthamoeba and toxicity on the eye surface. Chem. Biol. Drug Des., 2017, 90(3), 406-416.
[http://dx.doi.org/10.1111/cbdd.12958] [PMID: 28135787]
[145]
Imran, M.; Muazzam, A.G.; Habib, A.; Matin, A. Synthesis, characterization and amoebicidal potential of locally synthesized TiO2 nanoparticles against pathogenic Acanthamoeba trophozoites in vitro. J. Photochem. Photobiol. B, 2016, 159, 125-132.
[http://dx.doi.org/10.1016/j.jphotobiol.2016.03.014] [PMID: 27054875]
[146]
Siddiqui, R.; Syed, A.; Tomas, S.; Prieto-Garcia, J.; Khan, N.A. Effect of free versus liposomal-complexed pentamidine isethionate on biological characteristics of Acanthamoeba castellanii in vitro. J. Med. Microbiol., 2009, 58(Pt 3), 327-330.
[http://dx.doi.org/10.1099/jmm.0.006494-0] [PMID: 19208882]
[147]
Siddiqui, R.; Lakhundi, S.; Khan, N.A. Status of the effectiveness of contact lens solutions against keratitis-causing pathogens. Cont. Lens Anterior Eye, 2015, 38(1), 34-38.
[http://dx.doi.org/10.1016/j.clae.2014.09.001] [PMID: 25280981]
[148]
Abjani, F.; Khan, N.A.; Yousuf, F.A.; Siddiqui, R. Targeting cyst wall is an effective strategy in improving the efficacy of marketed contact lens disinfecting solutions against Acanthamoeba castellanii cysts. Cont. Lens Anterior Eye, 2016, 39(3), 239-243.
[http://dx.doi.org/10.1016/j.clae.2015.11.004] [PMID: 26675112]
[149]
Shayani Rad, M.; Khameneh, B.; Sabeti, Z.; Mohajeri, S.A.; Fazly Bazzaz, B.S. Antibacterial activity of silver nanoparticle-loaded soft contact lens materials: the effect of monomer composition. Curr. Eye Res., 2016, 41(10), 1286-1293.
[http://dx.doi.org/10.3109/02713683.2015.1123726] [PMID: 27212193]
[150]
Hebeish, A.; El-Rafie, M.H.; El-Sheikh, M.A.; Seleem, A.A.; El-Naggar, M.E. Antimicrobial wound dressing and anti-inflammatory efficacy of silver nanoparticles. Int. J. Biol. Macromol., 2014, 65, 509-515.
[http://dx.doi.org/10.1016/j.ijbiomac.2014.01.071] [PMID: 24530328]
[151]
Szczotka-Flynn, L.B.; Pearlman, E.; Ghannoum, M. Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review. Eye Contact Lens, 2010, 36(2), 116-129.
[http://dx.doi.org/10.1097/ICL.0b013e3181d20cae] [PMID: 20168237]
[152]
Willcox, M.D.P.; Hume, E.B.H.; Vijay, A.K.; Petcavichc, R. Ability of silver-impregnated contact lenses to control microbial growth and colonization. J. Optom., 2010, 3, 143-148.
[http://dx.doi.org/10.1016/S1888-4296(10)70020-0]
[153]
Siddiqui, R.; Aqeel, Y.; Khan, N.A. The use of dimethyl sulfoxide in contact lens disinfectants is a potential preventative strategy against contracting Acanthamoeba keratitis. Cont. Lens Anterior Eye, 2016, 39(5), 389-393.
[http://dx.doi.org/10.1016/j.clae.2016.04.004] [PMID: 27133448]
[154]
Aqeel, Y.; Siddiqui, R.; Anwar, A.; Shah, M.R.; Khoja, S.; Khan, N.A. Photochemotherapeutic strategy against Acanthamoeba infections. Antimicrob. Agents Chemother., 2015, 59(6), 3031-3041.
[http://dx.doi.org/10.1128/AAC.05126-14] [PMID: 25753633]
[155]
Aqeel, Y.; Siddiqui, R.; Anwar, A.; Shah, M.R.; Khan, N.A. Gold nanoparticle conjugation enhances the antiacanthamoebic effects of chlorhexidine. Antimicrob. Agents Chemother., 2015, 60(3), 1283-1288.
[http://dx.doi.org/10.1128/AAC.01123-15] [PMID: 26666949]
[156]
Khan, N.A. Acanthamoeba: Biology and Pathogenesis; Caister Academic Press: Linton, Cambs, UK, 2009. 290pp.


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Article Details

VOLUME: 26
ISSUE: 30
Year: 2019
Page: [5711 - 5726]
Pages: 16
DOI: 10.2174/0929867325666180510125633
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