Modern Approaches for the Discovery of Anti-Infectious Drugs for the Treatment of Neglected Diseases

Author(s): Carolina L. Bellera, Maria L. Sbaraglini, Alan Talevi*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 5 , 2018

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Graphical Abstract:


Neglected diseases comprise a number of infectious diseases historically endemic to low- and middle-income countries, though recently they have spread to high-income countries due to human migrations. In the past, pharmaceutical companies have shown hesitant to invest in these health conditions, due to the limited return on investment. As a result, the role of the academic sector and not-for-profit organizations in the discovery of new drugs for neglected diseases has been particularly relevant.

Here, we review recent applications of modern drug discovery technologies in the field of neglected diseases, including high-throughput screening, in silico screening and computer-aided drug design. The suitability and perspectives of each approach are discussed depending on the context, along with the technology and translational gaps influencing them.

Keywords: Drug repurposing, Drug repositioning, In silico screening, Virtual screening, High-throughput screening, Computer- aided drug discovery, Neglected diseases, Infectious diseases.

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Article Details

Year: 2018
Page: [369 - 381]
Pages: 13
DOI: 10.2174/1568026618666180509151146
Price: $65

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PDF: 35