The vascular endothelium plays an important role to maintain the functional integrity of
the cardiovascular system. The synthesis and secretion of substances with biological activity such
as prostacyclin and NO give endothelium the vasodilator, antithrombotic, and antiatherosclerotic
properties. Endothelial dysfunction participates in the genesis of HTA, but also hypertension
produces endothelial damage. The major class of antihypertensive drugs has beneficial effects in the
recuperation of the endothelial function, actions that are contributing to explain the impact of the
adequate control of HTA in the reduction of CV events.
Keywords: Hypertension, endothelial function, cardiovascular system, biological activity, HTA, antihypertensive drugs.
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