The Effect of Tranexamic Acid on Preventing Post-partum Hemorrhage Due to Uterine Atony: A Triple-blind Randomized Clinical Trial

Author(s): Mahvash Zargar*, Roshan Nikbakht, Mahzad Ahmadi.

Journal Name: Current Clinical Pharmacology

Volume 13 , Issue 2 , 2018

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Abstract:

Background: Postpartum haemorrhage (PPH) is an important cause of early maternal death which needs to be controlled.

Objective: This study was designed to compare the effect of intravenous tranexamic acid (TXA) and prostaglandin analogue on reducing PPH resulted from uterine atony in women undergoing C section or vaginal delivery.

Method: A randomized, triple-blind, placebo-controlled study was conducted on 248 pregnant women with PPH due to uterine atony who were randomly assigned into two groups of TXA as the intervention group (n=124) and prostaglandin analogue as the control group (n=124). The intervention group received 4 g TXA for an hour and then 1 g over 6 hours infusion intravenously and the control group received prostaglandin analogue.

Results: Postoperative bleeding did not significantly differ between the two groups (68.2±6.1 ml and 69.1±175.73 ml, respectively, P =0.6). Moreover, hemoglobin declines were 1±0.4 g/dl and 1.2±0.5 g/dL in TXA and prostaglandin group respectively, indicating that the difference was not statistically significant (P =0.7).

Conclusion: The results of the present study showed that administrating intravenous TXA had comparable effects with prostaglandin analogue on reducing PPH in women with uterine atony and in those undergoing C section or vaginal delivery. Therefore, TXA can be used instead of prostaglandin in managing such patients.

Keywords: Tranexamic acid, uterine atony, hemorrhage, pregnancy, antifibrinolytic agents, prostaglandin analogue.

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2018
Page: [136 - 139]
Pages: 4
DOI: 10.2174/1574884713666180507101002

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