Preparation, Optimization, In vitro Evaluation and Ex vivo Permeation Studies of Finasteride loaded gel Formulations Prepared by using Response Surface Methodology

Title:Preparation, Optimization, In vitro Evaluation and Ex vivo Permeation Studies of Finasteride loaded gel Formulations Prepared by using Response Surface Methodology

Volume: 15 Issue: 9

Author(s): Muhammad Zia Ullah Khan, Petre Makreski and Ghulam Murtaza*

Affiliation:

• Department of Pharmacy, COMSATS University Islamabad (Abbottabad Campus), Abbottabad,Pakistan

Keywords: Finasteride, topical gel, optimization, response surface methodology, central composite design, synergistic.

Abstract: Objectives: The aim of the present explorative study was to prepare and optimize finasteride loaded topical gel formulations by using three factor [propylene glycol (PG), Tween® 80, and sodium lauryl sulphate (SLS)], five level central composite design.

Results: Optimized finasteride topical gel formulation (F4), containing PG, Tween® 80, and SLS in a concentration of 0.8 mg, 0.4 mg and 0.2 mg, respectively, showed 6-fold higher values of cumulative drug release, flux, partition coefficient, input rate, lag time, and diffusion coefficient, when compared to control formulation without permeation enhancer.

Conclusion: Finally, it can be concluded that finasteride permeation was enhanced by PG, tween® 80 and SLS individually, while in combination only PG along with tween® 80 had synergistic and more pronounced effect on flux, permeability coefficient and input rate while antagonistic effect on lag time and diffusion coefficient was observed.

Cite this article as:

Khan Zia Ullah Muhammad , Makreski Petre and Murtaza Ghulam *, Preparation, Optimization, In vitro Evaluation and Ex vivo Permeation Studies of Finasteride loaded gel Formulations Prepared by using Response Surface Methodology, Current Drug Delivery 2018; 15 (9) . https://dx.doi.org/10.2174/1567201815666180502165436