Synthesis and Cytotoxicity Studies on Novel Piperazinylacetamides

Author(s): Eman Bobtaina, Enise Ece Gurdal*, Irem Durmaz, Rengul Cetin Atalay, Mine Yarim.

Journal Name: Letters in Drug Design & Discovery

Volume 16 , Issue 1 , 2019

Submit Manuscript
Submit Proposal

Graphical Abstract:


Abstract:

Background: In this study, nine novel compounds, bearing N-[2-(4-substituted piperazine-1-yl)acetyl]-N’-[bis-(4-fluorophenyl)methyl]piperazine structures were synthesized.

Methods: Their cytotoxic properties were evaluated in vitro by NCI-60 Sulforhodamine B (SRB) assay against human cancer cell lines: Huh7 (hepatocellular), MCF7 (breast) and HCT116 (colorectal).

Results and Conclusion: According to the activity data, most of the compounds are more cytotoxic than 5-fluorouracil against Huh7 and HCT116 cancer cell lines.

Keywords: Acetamide, anticancer, benzhydrylpiperazine, cytotoxicity, piperazine, sulforhodamine B.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 16
ISSUE: 1
Year: 2019
Page: [45 - 51]
Pages: 7
DOI: 10.2174/1570180815666180501124009
Price: $58

Article Metrics

PDF: 15
HTML: 4