Recent Progress of Marine Polypeptides as Anticancer Agents

Author(s): Lanhong Zheng, Yixin Xu, Xiukun Lin*, Zhixin Yuan, Minghua Liu, Shousong Cao, Fuming Zhang, Robert J. Linhardt.

Journal Name: Recent Patents on Anti-Cancer Drug Discovery

Volume 13 , Issue 4 , 2018

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Abstract:

Background: Marine environment constitutes an almost infinite resource for novel anticancer drug discovery. The biodiversity of marine organisms provides a rich source for the discovery and development of novel anticancer peptides in the treatment of human cancer. Marine peptides represent a new opportunity to obtain lead compounds in biomedical field, particularly for cancer therapy.

Objective: Providing an insight of the recent progress of patented marine peptides and presenting information about the structures and mechanistic mode of anticancer activities of these marine peptides.

Methods: We reviewed recent progress on the patented anticancer peptides from marine organisms according to their targets on different signal pathways. This work focuses on relevant recent patents (2010-2018) that entail the anticancer activity with associated mechanism and related molecular diversity of marine peptides. The related cellular signaling pathways for novel peptides that induce apoptosis and affect tubulin-microtubule equilibrium, angiogenesis and kinase activity that are related to the anticancer and related pharmacological properties are also discussed.

Results: The recent patents (2010-2018) of marine peptides with anticancer activity were reviewed, and the anticancer activity of marine peptides with associated mechanism and related molecular diversity of marine peptides were also discussed.

Conclusion: Marine peptides possess chemical diversity and display potent anticancer activity via targeting different signal pathways. Some of the marine peptides are promising to be developed as novel anticancer agents.

Keywords: Anticancer, apoptosis, angiogenesis, marine organisms, peptides/polypeptides, tubulin-microtubule equilibrium.

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2018
Page: [445 - 454]
Pages: 10
DOI: 10.2174/1574892813666180430110033
Price: $58

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