Background: Progesterone is a sex steroid hormone. Since it has been discovered, it is widely used in the
prevention of spontaneous preterm birth, hormone replacement therapy and other gynecological conditions.
Methods: We will review the progesterone preparations based on a comprehensive study of papers and patents from
the traditional preparations up through the very recent literatures.
Results: This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to
prepare progesterone preparations.
Conclusion: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can
be greatly increased.