Background and Objective: Cordia verbenacea DC (C. verbenacea) extract has
been widely used in Brazilian traditional medicine to treat topical inflammatory processes
and has shown healing activity. Moreover, the extract showed activity against coli and
Staphylococcus aureus strains. Natural Rubber Latex (NRL) membrane has a potential to
stimulate wound healing process, to accelerate healing of cutaneous chronic ulcers in humans,
cellular adhesion and increase vascularization Recent studies have used the NRL for
Drug Delivery Systems (DDS). In this work, it was developed an NRL membrane was developed
containing C. verbenacea using NRL as a carrier and physical, chemical and biological
characterization were performed to evaluate its potential as a system release of extract
for DDS. Fourier transform infrared spectroscopy (FTIR) showed no chemical interactions
between the extract and NRL, which influence its mechanical behavior. C. verbenacea
was adsorbed by the NRL membrane along all of its surface.
Conclusion: Kinetic release profile showed that NRL membrane can release the extract for
up to 18% during 80 hours and it obeys a bi-exponential function. In vitro cytotoxicity and
hemolysis assay showed that the extract loaded NRL membrane presented no cell damage
effects and no cytotoxicity at a concentration of 100-10%. The results showed that the NRL
membrane is a potential and effective model of C. verbenacea release.
Keywords: Natural rubber latex, Cordia verbenacea, NRL membranes, vegetable extract, cytotoxicity,
hemolysis, sustained released.
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