Background: Qualitative and quantitative analysis of atypical antipsychotic drugs used for
the treatment of schizophrenia, depression, anxiety, and bipolar disorder obtaining satisfactory results
can be ensured by voltammetric techniques. The aim of this review is to present the application of voltammetric
techniques developed for the determination of the atypical antipsychotic drugs, which are
amisulpride, aripiprazole, clozapine, olanzapine, quetiapine fumarate, risperidone, sertindole, and ziprasidone,
in pharmaceutical dosage forms and biological samples.
Methods: Studies in the literature published between 2004 and 2017 based on the voltammetric determination
of atypical antipsychotic drugs were gathered using scientific databases. The results obtained
from these studies were combined and interpreted.
Results: Voltammetric techniques applied for the sensitive determination of trace amounts of the selected
atypical antipsychotic drugs in their pharmaceutical dosage forms and biological fluids were
compared. The best analysis conditions were obtained after the optimization of some parameters such as
buffer type, pH, and scan rate. For diffusion controlled electrode processes, it was observed that differential
pulse and square wave voltammetry methods were generally used for the sensitive quantitative
determination of the drugs, whereas stripping methods were used for the adsorption controlled electrode
processes. Detection limits were between 1.53×10-3 µM for clozapine and 0.97 µM for risperidone.
Conclusion: The electrodes used in the studies showed high selectivity, sensitivity, and good accuracy
with precision. The developed methods were also applied to pharmaceutical preparations of the drugs
and biological fluids with satisfactory results, without any interference from inactive excipients.