Molecular Targets of Phytochemicals for Skin Inflammation

Author(s): Jong-Eun Kim, Ki Won Lee*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 14 , 2018

Abstract:

Skin is a protective organ and the largest of the human body. Due to its pivotal role in aesthetic appearance, skin health has a significant impact on quality of life. Chronic inflammation of the skin often marks the beginning of various skin diseases. Immune-mediated responses serve to protect the body from external insults and require succinct control, and can lead to ongoing cellular damage and various skin conditions if left unchecked. Studies have shown that phytochemicals can alter processes involved in skin inflammation and alleviate the effects of aging, cancer, atopic dermatitis, psoriasis, and vitiligo. Direct molecular targets of some phytochemicals have been identified and their precise mechanisms of action investigated. In this review, we summarize recent findings on the effects of phytochemicals on skin inflammation and the mechanisms of action involved.

Keywords: Phytochemicals, skin inflammation, target, signal transduction, chronic inflammation, immune-mediated responses.

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Article Details

VOLUME: 24
ISSUE: 14
Year: 2018
Page: [1533 - 1550]
Pages: 18
DOI: 10.2174/1381612824666180426113247
Price: $65

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