Skin is a protective organ and the largest of the human body. Due to its pivotal role in aesthetic appearance,
skin health has a significant impact on quality of life. Chronic inflammation of the skin often marks the
beginning of various skin diseases. Immune-mediated responses serve to protect the body from external insults
and require succinct control, and can lead to ongoing cellular damage and various skin conditions if left unchecked.
Studies have shown that phytochemicals can alter processes involved in skin inflammation and alleviate
the effects of aging, cancer, atopic dermatitis, psoriasis, and vitiligo. Direct molecular targets of some phytochemicals
have been identified and their precise mechanisms of action investigated. In this review, we summarize
recent findings on the effects of phytochemicals on skin inflammation and the mechanisms of action involved.
Keywords: Phytochemicals, skin inflammation, target, signal transduction, chronic inflammation, immune-mediated responses.
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