Background and Objective: Previous studies revealed the association between serum Nterminal
pro-brain natriuretic peptide (NT-proBNP) level and chronic kidney diseases (CKD) in general
population. However, little is known about the association between serum NT-proBNP level and
incident CKD in patients with type 2 diabetes. Thus, we investigated the impact of serum NT-proBNP
level on incident CKD in patients with type 2 diabetes.
Method: We enrolled 211 type 2 diabetic patients without CKD in this cohort study. CKD was diagnosed
as estimated glomerular filtration rate <60 ml/min/1.73 m2. We divided the patients into three
groups according to the tertiles of serum NT-proBNP level. Univariates and multivariate hazard ratios
(HRs) for the incident CKD were calculated by Cox regression analyses.
Results: Over the median follow-up period of 7 years, 56 patients developed incident CKD. Log NTproBNP
was positively associated with incident CKD (HR 3.70, 95%CI 1.72-8.18, p <0.001). Compared
with the lowest level of serum NT-proBNP tertile (≤36 pg/mL), the highest level of serum NTproBNP
tertile (≥84 pg/mL) showed increased risk of incident CKD after adjusting age, sex, body
mass index, hemoglobin A1c, creatinine, smoking, usage of hypertension drug and urinary albumin
excretion at baseline examination (adjusted HR2.37, 95% CI 1.09-5.48, p = 0.028).
Conclusion: Serum NT-proBNP level is an independent biomarker for incident CKD in patients with
type 2 diabetes.