Background: A growing number of studies have indicated that hydrogen sulfide (H2S)
affects the development of diabetes and its complications, but the specific mechanism is not
Objective: To summarize the effects and recent molecular mechanisms of H2S in various diabetic
Methods: Articles regarding the role of H2S channels in diabetic complications and relevant mechanisms
were selected. Relevant articles published from 2006 to present were selected from PubMed.
The search terms were “hydrogen sulfide” and “diabetes”. Important references from selected articles
were also retrieved.
Results: The reduction of endogenous H2S contribute to diabetic injury and the supply of exogenous
H2S protect tissues from diabetic injury through anti-apoptosis, anti-fibrosis, inhibited oxidative stress
and inflammation in different complications, including cardiomyopathy, vascular injury, retinopathy,
nephropathy, and encephalopathy.
Conclusion: H2S may play an important role in diabetic complications and may be a potential target
for therapeutic intervention of diabetic related diseases.