Background: Terbinafine (TFH), an allylamine derivative, is the most effective
Objective: The present investigation was focused to formulate and optimize nanoemulsion
of TFH and converting them as a suitable transdermal Terbinafine Nanoemulsion
Gel (TFNG) to improve therapeutic efficacy, better dispersity, and storage stability in the
treatment of fungal infection.
Methods: The nanoemulsion was prepared by water titration method and characterized
for droplet size, polydispersity index (PDI), refractive index, drug content, viscosity, and
morphology. The nanoemulsion formulation was incorporated into the gel for controlled
release and evaluated for pH, drug content, and viscosity. Ex-vivo permeation study was
conducted using human cadaver skin on TFNG and a marketed gel.
Results: The formulation A1 showed the desired droplet size (133.0 ± 10.5 nm), PDI
(0.174 ± 0.01), refractive index (1.334±0.05), drug content (99.12 ± 2.5 %) and viscosity
(45.85 ± 4.60 cp). In ex-vivo permeation study, TFNG showed a significant (p<0.05) prolonged
release of TFH. TFNG showed a significant antifungal activity against Candida
albicans compared to marketed gel. Skin irritation study shows that the formulation is
safe for dermatological use. No significant changes (p>0.05) were found in the values of
pH, drug content and viscosity over the period of 3 months.
Conclusion: In conclusion, TFNG was found to have great potential to serve as a transdermal
preparation, excellent antifungal activity, and safe with better storage stability.