Abstract
This review summarizes the literature data regarding plant lectins as novel drug sources in the prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their structure and affinity. Most of the mushroom heterosides are known as β-glucans with β-(1→3)-glycosidic bonds. It is thought that their conformation, bonds, molecular size can modulate the immune response by triggering different receptors. The mechanism on normal and tumor cells of various plant and mushroom polysaccharides and lectins is briefly presented in this paper.
Keywords: Cancer, plant lectins, mushroom, mechanism, apoptosis, receptors.
Anti-Cancer Agents in Medicinal Chemistry
Title:Natural Macromolecules with Protective and Antitumor Activity
Volume: 18 Issue: 5
Author(s): Cioanca Oana, Trifan Adriana, Cornelia Mircea*, Scripcariu Dragos and Hancianu Monica
Affiliation:
- Department of Biochemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, P.O. Box: 700115, Iasi,Romania
Keywords: Cancer, plant lectins, mushroom, mechanism, apoptosis, receptors.
Abstract: This review summarizes the literature data regarding plant lectins as novel drug sources in the prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their structure and affinity. Most of the mushroom heterosides are known as β-glucans with β-(1→3)-glycosidic bonds. It is thought that their conformation, bonds, molecular size can modulate the immune response by triggering different receptors. The mechanism on normal and tumor cells of various plant and mushroom polysaccharides and lectins is briefly presented in this paper.
Export Options
About this article
Cite this article as:
Oana Cioanca, Adriana Trifan, Mircea Cornelia *, Dragos Scripcariu and Monica Hancianu, Natural Macromolecules with Protective and Antitumor Activity, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (5) . https://dx.doi.org/10.2174/1871520618666180425115029
DOI https://dx.doi.org/10.2174/1871520618666180425115029 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cancer/Testis Antigens Trigger Epithelial-Mesenchymal Transition and Genesis of Cancer Stem-Like Cells
Current Pharmaceutical Design Intraarticular Treatments for Osteoarthritis: New Perspectives
Current Drug Targets The Possible Use of Terpene Compounds in DC Immunotherapy against Cancer
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress
Current Pharmaceutical Design Antisense Technologies Targeting Fatty Acid Synthetic Enzymes
Recent Patents on Anti-Cancer Drug Discovery Targeting Protein-Protein and Protein-Nucleic Acid Interactions for Anti-HIV Therapy
Current Pharmaceutical Design Isolation and Characterization of a Lectin from Japanese Mottled Beans
Protein & Peptide Letters Subject Index to Volume 7
Combinatorial Chemistry & High Throughput Screening Using the Chou’s Pseudo Component to Predict the ncRNA Locations Based on the Improved K-Nearest Neighbor (iKNN) Classifier
Current Bioinformatics Triple-negative Breast Cancer and Poly(ADP-ribose) Polymerase Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Update of Peptides with Antibacterial Activity
Current Medicinal Chemistry Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy
Current Pharmaceutical Design MicroRNAs as Main Players in the Pathogenesis of Chronic Lymphocytic Leukemia
MicroRNA Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors
Current Medicinal Chemistry Prospects and Limitations of T Cell Receptor Gene Therapy
Current Gene Therapy Bisphosphonate Osteonecrosis (BON): Unanswered Questions and Research Possibilities
Reviews on Recent Clinical Trials Bariatric Surgery - Effects on Obesity and Related co-Morbidities
Current Diabetes Reviews T-Cell Dysregulation in Systemic Lupus Erythematosus: Pathophysiology and Opportunities for Biomarker Development
Current Rheumatology Reviews One Hundred Faces of Cyclopamine
Current Pharmaceutical Design Effects of Dietary Broccoli on Human in Vivo Caffeine Metabolism: A Pilot Study on a Group of Jordanian Volunteers
Current Drug Metabolism